Estrogen receptor alpha (ERα) has been recognized now for several decades as playing a
key role in reproduction and exerting functions in numerous nonreproductive tissues. In this …

Nitric oxide (NO) is a key signalling molecule in the cardiovascular, immune and central
nervous systems, and crucial steps in the regulation of NO bioavailability in health and …

Importance Previous trials have suggested that vasopressin and methylprednisolone
administered during in-hospital cardiac arrest might improve outcomes. Objective To …

Glucocorticoid (GC) anti-inflammatory effects generally require a prolonged onset of action
and involve genomic processes. Because of the rapidity of some of the GC effects, however …

All living organisms have developed a highly conserved and regulatory system, the stress
system, to cope with a broad spectrum of stressful stimuli that threaten, or are perceived as …

It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …

Fulminant myocarditis (FM) is characterized by a rapid progressive decline in cardiac
function and a high mortality rate. Since the first report of FM patients in the 1980s, several …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …

Over the past two decades, research has heavily emphasized basic mechanisms that
irreversibly damage brain cells after stroke. Much attention has focused on what makes …