Autism spectrum disorder (ASD) is a neurodevelopmental impairment characterized by
deficits in social interaction skills, impaired communication, and repetitive and restricted …

G-protein-coupled receptors (GPCRs) play critical roles in regulating brain function. Recent
advances have greatly expanded our understanding of these receptors as complex …

Autism spectrum disorder (ASD) is comprised of several conditions characterized by
alterations in social interaction, communication, and repetitive behaviors. Genetic and …

The neurobiological understanding of obsessive–compulsive disorder (OCD) includes
dysregulated frontostriatal circuitry and altered monoamine transmission. Repetitive …

Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …

Suboptimal decision-making strategies have been proposed to contribute to the
pathophysiology of addiction. Decision-making, however, arises from a collection of …

G-protein-coupled receptors can be constitutively activated following physical interaction
with intracellular proteins. The first example described was the constitutive activation of …

Hyperactivity in striatum is associated with compulsive behaviors in obsessive-compulsive
disorder (OCD) and related illnesses, but it is unclear whether this hyperactivity is due to …

Excessive grooming of Sapap3-KO mice has been used as a model of obsessive-
compulsive disorder (OCD). Previous studies suggest that dysregulation of cortico-striatal …

Glutamate is a major excitatory neurotransmitter, and impaired glutamate clearance
following synaptic release promotes spillover, inducing extra-synaptic signaling. The effects …