HIV-associated neurocognitive disorder

DB Clifford, BM Ances - The Lancet infectious diseases, 2013 - thelancet.com
Neurological involvement in HIV is often associated with cognitive impairment. Although
severe and progressive neurocognitive impairment has become rare in HIV clinics in the era …

Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management

RJ Ellis, MJ Marquine, M Kaul, JA Fields… - Nature Reviews …, 2023 - nature.com
People living with HIV are affected by the chronic consequences of neurocognitive
impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve …

Global prevalence and burden of HIV-associated neurocognitive disorder: a meta-analysis

Y Wang, M Liu, Q Lu, M Farrell, JM Lappin, J Shi, L Lu… - Neurology, 2020 - AAN Enterprises
Objective To characterize the prevalence and burden of HIV-associated neurocognitive
disorder (HAND) and assess associated factors in the global population with HIV. Methods …

Plasma concentration of the neurofilament light protein (NFL) is a biomarker of CNS injury in HIV infection: a cross-sectional study

M Gisslén, RW Price, U Andreasson, N Norgren… - …, 2016 - thelancet.com
Background Cerebrospinal fluid (CSF) neurofilament light chain protein (NFL) is a sensitive
marker of neuronal injury in a variety of neurodegenerative conditions, including the CNS …

HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

RK Heaton, DR Franklin, RJ Ellis, JA McCutchan… - Journal of …, 2011 - Springer
Combination antiretroviral therapy (CART) has greatly reduced medical morbidity and
mortality with HIV infection, but high rates of HIV-associated neurocognitive disorders …

CD4 nadir is a predictor of HIV neurocognitive impairment in the era of combination antiretroviral therapy

RJ Ellis, J Badiee, F Vaida, S Letendre, RK Heaton… - Aids, 2011 - journals.lww.com
Objective: Despite immune recovery in individuals on combination antiretroviral therapy
(CART), the frequency of HIV-associated neurocognitive disorders (HANDs) remains high …

The definition of HIV-associated neurocognitive disorders: are we overestimating the real prevalence?

M Gisslén, RW Price, S Nilsson - BMC infectious diseases, 2011 - Springer
Background A substantial prevalence of mild neurocognitive disorders has been reported in
HIV, also in patients treated with combination antiretroviral therapy (cART). This includes a …

Plasma sCD14 is a biomarker associated with impaired neurocognitive test performance in attention and learning domains in HIV infection

JL Lyons, H Uno, P Ancuta, A Kamat… - JAIDS Journal of …, 2011 - journals.lww.com
Objective: Mild forms of HIV-associated neurocognitive disorders (HAND) remain prevalent
in the era of combination antiretroviral therapy (cART). Although elevated …

Twelve-year neurocognitive decline in HIV is associated with comorbidities, not age: a CHARTER study

RK Heaton, RJ Ellis, B Tang, CM Marra, LH Rubin… - Brain, 2023 - academic.oup.com
Modern antiretroviral therapy (ART) has increased longevity of people with HIV and shifted
the age distribution of the HIV pandemic upward toward that of the general population. This …

Natural products as anti-HIV agents and role in HIV-associated neurocognitive disorders (HAND): a brief overview

KRV Kurapati, VS Atluri, T Samikkannu… - Frontiers in …, 2016 - frontiersin.org
As the threat of Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency
Syndrome (AIDS) persists to rise, effective drug treatments are required to treat the infected …