Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

A multitude of mechanisms are involved in the control of emotion and in the response to
stress. These incorporate mediators/targets as diverse as γ-aminobutyric acid (GABA) …

Rationale: Tolerance to delay of gratification, taken to reflect impulsiveness, has been
proposed to be under the preferential control of central serotonin (5-HT) processes …

One of the critical mechanisms by which alcohol heightens aggression involves forebrain
serotonin (5-HT) systems, possibly via actions on 5-HT 1A receptors. The present …

The selective, non-peptidergic corticotropin-releasing factor (CRF) 1 receptor antagonists,
CP154, 526 and DMP695, dose-dependently increased punished responses of rats in a …

Compounds varying in selectivity as 5-HT1A receptor antagonists have recently been
reported to produce benzodiazepine-like antianxiety effects in mice. To assess the cross …

Disturbances in behavioral inhibition are key features in several neurological and
psychiatric disorders, such as attention-deficit/hyperactivity disorder, Parkinson׳ s disease …

Rationale: Compounds varying in selectivity as 5-HT 1A receptor antagonists have recently
been reported to produce anxiolytic-like effects comparable to those of benzodiazepines in …

Over the last decade, many genetically modified mice have been developed as models for
psychiatric diseases such as anxiety. Limited availability of such mutant mice highlights the …

8-OH-DPAT [8-hydroxy-2-(di-N-propylamino) tetralin], a 5-HT1A receptor agonist, and S
15535 (4-benzodioxan-5-yl) 1-(indan-2-yl) piperazine, a partial agonist at 5-HT1A receptors …