Fibrinogen and fibrin are essential for hemostasis and are major factors in thrombosis,
wound healing, and several other biological functions and pathological conditions. The X …

Fibrinogen is a hexameric plasmatic glycoprotein composed of pairs of three chains (Aα, Bβ,
and γ), which play an essential role in hemostasis. Conversion of fibrinogen to insoluble …

Abstract SARS-CoV-2, the pathogenic agent of COVID-19, employs angiotensin converting
enzyme-2 (ACE2) as its cell entry receptor. Clinical data reveal that in severe COVID-19 …

Congenital fibrinogen disorders are classified into two types of plasma fibrinogen defects:
type I (quantitative fibrinogen deficiencies), that is, hypofibrinogenemia or afibrinogenemia …

The study of inherited fibrinogen disorders, characterized by extensive allelic heterogeneity,
allows the association of defined mutations with specific defects providing significant insight …

Fibrinogen is a complex protein playing a major role in coagulation. Congenital
afibrinogenemia, characterized by the complete absence of fibrinogen, is associated with …

JCM | Free Full-Text | Heterogeneity of Genotype–Phenotype in Congenital
Hypofibrinogenemia—A Review of Case Reports Associated with Bleeding and …

Background Numerous mutations in FGA, FGB or FGG lead to congenital fibrinogen
disorders (CFDs), but their epidemiology is not well characterized. The aim of this study was …

Congenital fibrinogen disorders are rare pathologies of the hemostasis, comprising
quantitative (afibrinogenemia, hypofibrinogenemia) and qualitative (dysfibrinogenemia and …

Hematologic diseases include a broad range of acquired and congenital disorders, many of
which affect plasma proteins that control hemostasis and immune responses. Therapeutic …