The PML gene encodes a tumour suppressor protein associated with a distinct subnuclear
domain, the nuclear body. Various functions have been attributed to the PML nuclear body …

It has become clear that the nucleus is organized into discrete structures. Although not
membrane bound, these structures are considered nuclear organelles. Widespread interest …

The promyelocytic leukemia (PML) nuclear body (also referred to as ND10, POD, and Kr
body) is involved in oncogenesis and viral infection. This subnuclear domain has been …

Daxx was first identified as a protein that binds the cytosolic domain of Fas and links this
receptor to an apoptosis pathway involving activation of Jun N‐terminal kinase (JNK). We …

It has been 10 years since the seminal discovery that a mutant form of a retinoid acid
receptor (RARα) is associated with acute promyelocytic leukemia (APL). This finding …

Promyelocytic leukemia (PML) has been implicated in a variety of functions, including
control of TP53 function and modulation of cellular senescence. Sumolated PML is the …

Snail/Slug family proteins have been identified in diverse species of both vertebrates and
invertebrates. The proteins contain four to six zinc fingers and function as DNA-binding …

The small ubiquitin-like modifier (SUMO) is covalently attached to lysine residues in target
proteins and in doing so changes the properties of the modified protein. Here we examine …

Pathogenesis of acute promyelocytic leukemia (APL) has been proposed to involve
transcriptional repression through enhanced corepressors binding onto RARA moieties of …

The growth suppressor promyelocytic leukemia protein (PML) is disrupted by the
chromosomal translocation t (15; 17) in acute promyelocytic leukemia (APL). PML plays a …