Experimental genomics in combination with the growing body of sequence information
promise to revolutionize the way cells and cellular processes are studied. Information on …

Background: The recent flood of data from genome sequences and functional genomics has
given rise to new field, bioinformatics, which combines elements of biology and computer …

Genomic sequencing has made it clear that a large fraction of the genes specifying the core
biological functions are shared by all eukaryotes. Knowledge of the biological role of such …

Background Recent advances in proteomics technologies such as two-hybrid, phage
display and mass spectrometry have enabled us to create a detailed map of biomolecular …

Determining the effect of gene deletion is a fundamental approach to understanding gene
function. Conventional genetic screens exhibit biases, and genes contributing to a …

A principal challenge currently facing biologists is how to connect the complete DNA
sequence of an organism to its development and behaviour. Large-scale targeted-deletions …

We describe a largely unbiased method for rapid and large-scale proteome analysis by
multidimensional liquid chromatography, tandem mass spectrometry, and database …

Genomic sequencing has made it clear that a large fraction of the genes specifying the core
biological functions are shared by all eukaryotes. Knowledge of the biological role of such …

The recent abundance of genome sequence data has brought an urgent need for systematic
proteomics to decipher the encoded protein networks that dictate cellular function. To date …

We have sequenced and annotated the genome of fission yeast (Schizosaccharomyces
pombe), which contains the smallest number of protein-coding genes yet recorded for a …