Our understanding of human colonic motility, and autonomic reflexes that generate motor
patterns, has increased markedly through high-resolution manometry. Details of the motor …

Gastrointestinal (GI) motility function and its regulation is a complex process involving
collaboration and communication of multiple cell types such as enteric neurons, interstitial …

Interstitial cells of Cajal (ICC) are implicated in the regulation of gut peristalsis and are
immunostained by antibodies against Kit (CD117), a tyrosine kinase receptor. Most …

Networks of interstitial cells of Cajal embedded in the musculature of the gastrointestinal
tract are involved in the generation of electrical pacemaker activity for gastrointestinal …

Background & Aims: A variety of gastrointestinal motility disorders have been attributed to
alterations of interstitial cells of Cajal and malformations of the enteric nervous system. This …

The morphological features of interstitial cells of Cajal (ICC) in the gastrointestinal (GI) tract
are described based on observations of laboratory animals including mice, rats and guinea …

Neurohumoral substances and their receptors play a major part in the complex regulation of
gastrointestinal motility and have therefore been the predominant targets for drug …

This review will focus on the pacemaker mechanisms underlying gastrointestinal autonomic
rhythmicity in an attempt to elucidate the differences and similarities between the pacemaker …

Chronic intestinal pseudo-obstruction (CIP) represents a particularly difficult clinical
challenge. It is a rare and highly morbid syndrome characterised by impaired …

▪ Abstract The main contributors to increases in [Ca2+] i and tension are the entry of Ca2+
through voltage-dependent channels opened by depolarization or during action potential …