Anecdotal evidence that cannabis preparations have medical benefits together with the
discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …

Endocannabinoids (eCBs) are amongst the most ubiquitous signaling molecules in the
nervous system. Over the past few decades, observations based on a large volume of work …

Bidirectional communication between neurons and astrocytes shapes synaptic plasticity and
behavior. D-serine is a necessary co-agonist of synaptic N-methyl-D-aspartate receptors …

The endocannabinoid system consists of endogenous cannabinoids (endocannabinoids),
the enzymes that synthesize and degrade endocannabinoids, and the receptors that …

The endocannabinoid system (ECS) functions to adjust behavior and metabolism according
to environmental changes in food availability. Its actions range from the regulation of …

Background: Cannabinoid has long been used for medicinal purposes. Cannabinoid
signaling has been considered the therapeutic target for treating pain, addiction, obesity …

Drug addiction is a chronic relapsing disorder that produces a dramatic global health burden
worldwide. Not effective treatment of drug addiction is currently available probably due to the …

Complex roles for astrocytes in health and disease continue to emerge, highlighting this
class of cells as integral to function and dysfunction of the nervous system. In particular …

Polyunsaturated fatty acids (PUFAs) are lipid derivatives of omega-3 (docosahexaenoic
acid, DHA, and eicosapentaenoic acid, EPA) or of omega-6 (arachidonic acid, ARA) …

Receptors of leptin, the prototypical adipokine, are expressed throughout the cortex and
several other areas of the brain. Although typically studied for its role in energy intake and …