Heart disease and stroke statistics—2022 update: a report from the American Heart Association

CW Tsao, AW Aday, ZI Almarzooq, A Alonso… - Circulation, 2022 - Am Heart Assoc
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Heart disease and stroke statistics—2023 update: a report from the American Heart Association

CW Tsao, AW Aday, ZI Almarzooq, CAM Anderson… - Circulation, 2023 - Am Heart Assoc
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Large-scale integration of the plasma proteome with genetics and disease

E Ferkingstad, P Sulem, BA Atlason… - Nature …, 2021 - nature.com
The plasma proteome can help bridge the gap between the genome and diseases. Here we
describe genome-wide association studies (GWASs) of plasma protein levels measured with …

Epidemiology and prevention of venous thromboembolism

PL Lutsey, NA Zakai - Nature Reviews Cardiology, 2023 - nature.com
Venous thromboembolism, that consists of the interrelated conditions deep-vein thrombosis
and pulmonary embolism, is an under-appreciated vascular disease. In Western regions …

Polygenic risk scores for cardiovascular disease: a scientific statement from the American Heart Association

JW O'Sullivan, S Raghavan, C Marquez-Luna… - Circulation, 2022 - Am Heart Assoc
Cardiovascular disease is the leading contributor to years lost due to disability or premature
death among adults. Current efforts focus on risk prediction and risk factor mitigation ‚which …

Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism

J Ghouse, V Tragante, G Ahlberg, SA Rand… - Nature …, 2023 - nature.com
We report a genome-wide association study of venous thromboembolism (VTE)
incorporating 81,190 cases and 1,419,671 controls sampled from six cohorts. We identify 93 …

Development of a clinical polygenic risk score assay and reporting workflow

L Hao, P Kraft, GF Berriz, ED Hynes, C Koch… - Nature medicine, 2022 - nature.com
Implementation of polygenic risk scores (PRS) may improve disease prevention and
management but poses several challenges: the construction of clinically valid assays …

Associations between blood type and COVID-19 infection, intubation, and death

M Zietz, J Zucker, NP Tatonetti - Nature communications, 2020 - nature.com
The rapid global spread of the novel coronavirus SARS-CoV-2 has strained healthcare and
testing resources, making the identification and prioritization of individuals most at-risk a …

Inflammation, infection and venous thromboembolism

ME Colling, BE Tourdot, Y Kanthi - Circulation research, 2021 - Am Heart Assoc
The association between inflammation, infection, and venous thrombosis has long been
recognized; yet, only in the last decades have we begun to understand the mechanisms …

Clinical and genetic risk factors for acute incident venous thromboembolism in ambulatory patients with COVID-19

JQ Xie, A Prats-Uribe, Q Feng, YH Wang… - JAMA internal …, 2022 - jamanetwork.com
Importance The risk of venous thromboembolism (VTE) in ambulatory COVID-19 is
controversial. In addition, the association of vaccination with COVID-19–related VTE and …