Microbiome-based therapeutics

MT Sorbara, EG Pamer - Nature Reviews Microbiology, 2022 - nature.com
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …

Microbiota-mediated colonization resistance: mechanisms and regulation

G Caballero-Flores, JM Pickard, G Núñez - Nature Reviews …, 2023 - nature.com
A dense and diverse microbial community inhabits the gut and many epithelial surfaces.
Referred to as the microbiota, it co-evolved with the host and is beneficial for many host …

The gut microbiota in inflammatory bowel disease

P Qiu, T Ishimoto, L Fu, J Zhang, Z Zhang… - Frontiers in cellular and …, 2022 - frontiersin.org
Epidemiological surveys indicate that the incidence of inflammatory bowel disease (IBD) is
increasing rapidly with the continuous growth of the economy. A large number of studies …

The microbiome-shaping roles of bacteriocins

S Heilbronner, B Krismer, H Brötz-Oesterhelt… - Nature Reviews …, 2021 - nature.com
The microbiomes on human body surfaces affect health in multiple ways. They include not
only commensal or mutualistic bacteria but also potentially pathogenic bacteria, which can …

Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations

S Soltani, R Hammami, PD Cotter… - FEMS microbiology …, 2021 - academic.oup.com
In recent decades, bacteriocins have received substantial attention as antimicrobial
compounds. Although bacteriocins have been predominantly exploited as food …

Host–microbiota interactions in inflammatory bowel disease

R Caruso, BC Lo, G Núñez - Nature Reviews Immunology, 2020 - nature.com
The mammalian intestine is colonized by trillions of microorganisms that have co-evolved
with the host in a symbiotic relationship. The presence of large numbers of symbionts near …

Bacterial siderophores in community and host interactions

J Kramer, Ö Özkaya, R Kümmerli - Nature Reviews Microbiology, 2020 - nature.com
Iron is an essential trace element for most organisms. A common way for bacteria to acquire
this nutrient is through the secretion of siderophores, which are secondary metabolites that …

Gut microbiome stability and resilience: elucidating the response to perturbations in order to modulate gut health

M Fassarella, EE Blaak, J Penders, A Nauta, H Smidt… - Gut, 2021 - gut.bmj.com
The human gut microbiome is a complex ecosystem, densely colonised by thousands of
microbial species. It varies among individuals and depends on host genotype and …

Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease

JM Pickard, MY Zeng, R Caruso… - Immunological …, 2017 - Wiley Online Library
The intestinal tract of mammals is colonized by a large number of microorganisms including
trillions of bacteria that are referred to collectively as the gut microbiota. These indigenous …

Gut microbiota and colonization resistance against bacterial enteric infection

QR Ducarmon, RD Zwittink, BVH Hornung… - Microbiology and …, 2019 - Am Soc Microbiol
The gut microbiome is critical in providing resistance against colonization by exogenous
microorganisms. The mechanisms via which the gut microbiota provide colonization …