The use of hypoxia models in cell culture has allowed the characterization of the hypoxia
response at the cellular, biochemical and molecular levels. Although a decrease in oxygen …

Studies of the regulation of erythropoietin (EPO) production by the liver and kidneys, one of
the classical physiological responses to hypoxia, led to the discovery of human oxygen …

During exercise the cardiovascular system has to warrant substrate supply to working
muscle. The main function of red blood cells in exercise is the transport of O2 from the lungs …

In mammals, erythropoietin (EPO), produced in the kidney, is essential for bone marrow
erythropoiesis, and hypoxia induction of EPO production provides for the important …

Over the past decade, PAS domains have been identified in dozens of signal transduction
molecules and various forms have been found in animals, plants, and prokaryotes. In this …

This article outlines the need for a homeostatic response to alterations in cellular
oxygenation. It describes work on erythropoietin control that led to the discovery of the …

CKD progresses with fibrosis and erythropoietin (Epo)-dependent anemia, leading to
increased cardiovascular complications, but the mechanisms linking Epo-dependent …

The pronounced radiosensitivity of renal tissue limits the total radiotherapeutic dose that can
be applied safely to treatment volumes that include the kidneys. The incidence of clinical …

We measured blood erythropoietin (EPO) concentration, arterial O2 saturation (SaO2), and
urine Po 2 in 48 subjects (32 men and 16 women) at sea level and after 6 and 24 h at …

Long overlooked as the virtual compartment and then strictly characterized through
descriptive morphologic analysis, the renal interstitium has finally been associated with …