Nicotinic acetylcholine receptors (nAChRs) are a subfamily of pentameric ligand-gated ion
channels with members identified in most eumetazoan clades. In vertebrates, they are …

Sensory systems experience a period of intrinsically generated neural activity before
maturation is complete and sensory transduction occurs. Here we review evidence …

In the developing auditory system, spontaneous activity generated in the cochleae
propagates into the central nervous system to promote circuit formation. The effects of …

The cochlea is an important sensory organ for both balance and sound perception, and the
formation of the cochlea is a complex developmental process. The development of the …

Hearing involves a stereotyped neural network communicating cochlea and brain. How this
sensorineural circuit assembles is largely unknown. The cochlea houses two types of …

The organ of Corti, the auditory mammalian sensory epithelium, contains two types of
mechanotransducer cells, inner hair cells (IHCs) and outer hair cells (OHCs). IHCs are …

During development, inner hair cells (IHCs) in the mammalian cochlea are unresponsive to
acoustic stimuli but instead exhibit spontaneous activity. During this same period, neurons …

Neurons of the medial olivary complex inhibit cochlear hair cells through the activation of
α9α10-containing nicotinic acetylcholine receptors (nAChRs). Efforts to study the localization …

Mammalian inner hair cells (IHCs) transduce sound into depolarization and transmitter
release. Big conductance and voltage‐and Ca2+‐activated K+ (BK) channels are …

Cochlear outer hair cells (OHCs) are electromotile and are implicated in mechanisms of
amplification of responses to sound that enhance sound sensitivity and frequency tuning …