The neglected gut microbiome: Fungi, Protozoa, and bacteriophages in inflammatory bowel disease

GL Guzzo, JM Andrews… - Inflammatory bowel …, 2022 - academic.oup.com
The gut microbiome has been implicated in the pathogenesis of inflammatory bowel disease
(IBD). Studies suggest that the IBD gut microbiome is less diverse than that of the unaffected …

Helminth-derived biomacromolecules as therapeutic agents for treating inflammatory and infectious diseases: What lessons do we get from recent findings?

P Chakraborty, V Aravindhan, S Mukherjee - International Journal of …, 2023 - Elsevier
Despite the tremendous progress in healthcare sectors, a number of life-threatening
infectious, inflammatory, and autoimmune diseases are continuously challenging mankind …

[HTML][HTML] Microbial Anti-Inflammatory Molecule (MAM) from Faecalibacterium prausnitzii Shows a Protective Effect on DNBS and DSS-Induced Colitis Model in Mice …

NM Breyner, C Michon, CS de Sousa… - Frontiers in …, 2017 - frontiersin.org
Faecalibacterium prausnitzii and its supernatant showed protective effects in different
chemically-induced colitis models in mice. Recently, we described 7 peptides found in the F …

Helminths in the gastrointestinal tract as modulators of immunity and pathology

F Varyani, JO Fleming… - American Journal of …, 2017 - journals.physiology.org
Helminth parasites are highly prevalent in many low-and middle-income countries, in which
inflammatory bowel disease and other immunopathologies are less frequent than in the …

[HTML][HTML] Parasite-derived proteins for the treatment of allergies and autoimmune diseases

Z Wu, L Wang, Y Tang, X Sun - Frontiers in microbiology, 2017 - frontiersin.org
The morbidity associated with atopic diseases and immune dysregulation disorders such as
asthma, food allergies, multiple sclerosis, atopic dermatitis, type 1 diabetes mellitus, and …

Potential of human helminth therapy for resolution of inflammatory bowel disease: The future ahead

T Arai, F Lopes - Experimental Parasitology, 2022 - Elsevier
Inflammatory bowel disease (IBD) is associated with a dysregulated mucosal immune
response in the gastrointestinal tract. The number of patients with IBD has increased …

[HTML][HTML] Schistosoma japonicum Cystatin Alleviates Sepsis Through Activating Regulatory Macrophages

H Xie, L Wu, X Chen, S Gao, H Li, Y Yuan… - Frontiers in Cellular …, 2021 - frontiersin.org
Multi-organ failure caused by the inflammatory cytokine storm induced by severe infection is
the major cause of death for sepsis. Sj-Cys is a cysteine protease inhibitor secreted by …

[HTML][HTML] The Tapeworm Hymenolepis diminuta as an Important Model Organism in the Experimental Parasitology of the 21st Century

A Sulima-Celińska, A Kalinowska, D Młocicki - Pathogens, 2022 - mdpi.com
The tapeworm Hymenolepis diminuta is a common parasite of the small intestine in rodents
but it can also infect humans. Due to its characteristics and ease of maintenance in the …

[HTML][HTML] Macrophage Gal/GalNAc lectin 2 (MGL2)+ peritoneal antigen presenting cells during Fasciola hepatica infection are essential for regulatory T cell induction

M Costa, V da Costa, P Lores, M Landeira… - Scientific Reports, 2022 - nature.com
Fasciola hepatica, one of the agents that causes fasciolosis, modulates the host immune
system to allow parasite survival in the host. F. hepatica expresses carbohydrate-containing …

Inflammatory bowel diseases, the hygiene hypothesis and the other side of the microbiota: parasites and fungi

S Panelli, S Epis, L Cococcioni, M Perini… - Pharmacological …, 2020 - Elsevier
This review tackles the concept of the evolutionary mismatch, in relation with the reduction of
the prevalence of the so-called “dirty old friends”. These formed the variegated community of …