Cationic lipids are one of the most widely used nonviral vectors for gene delivery and are
especially attractive because they can be easily synthesized and extensively characterized …

Synthetic cationic lipids, which form complexes (lipoplexes) with polyanionic DNA, are
presently the most widely used constituents of nonviral gene carriers. A large number of …

Abstract Aims Long-QT syndromes (LQTS) are mostly autosomal-dominant congenital
disorders associated with a 1: 1000 mutation frequency, cardiac arrest, and sudden death …

Spermines are naturally abundant polyamines that partially condense nucleic acids and
exhibit the proton-sponge effect in an acidic environment. However, spermines show a …

Gene therapy requires an effective and safe delivery vehicle for nucleic acids. In the case of
non-viral vehicles, including cationic liposomes, the structure of compounds composing …

In this work we have synthesized a new series of cationic carbon nanotubes (CNTs) for
siRNA binding. Both single-and multi-walled CNTs have been modified by addition or …

Purpose To study the efficiency of novel synthetic N 1, N 12-diacyl spermines on DNA and
siRNA binding, and to compare their transfection efficiency with viability in cell lines …

Gene silencing by siRNA (synthetic dsRNA of 21-25 nucleotides) is a well established
biological tool in gene expression studies and has a promising therapeutic potential for …

Nonviral siRNA vectors prepared by the direct mixing of siRNA and mixtures of an
asymmetric N 4, N 9-diacyl spermine conjugate, N 4-linoleoyl-N 9-oleoyl-1, 12-diamino-4, 9 …

It is important to obtain structure–activity relationship (SAR) data across cationic lipids for the
self-assembly and nonviral intracellular delivery of siRNA. The aims of this work are to carry …