Melanin synthesis involves the successful coordination of metabolic pathways across
multiple intracellular compartments including the melanosome, mitochondria, ER/Golgi, and …

The leptomeninges, the cerebrospinal-fluid-filled tissues surrounding the central nervous
system, play host to various pathologies including infection, neuroinflammation and …

Background The aim of this study is to build a prognostic model for cutaneous melanoma
(CM) using fatty acid-related genes and evaluate its capacity for predicting prognosis …

Seipin is one key mediator of lipid metabolism that is highly expressed in adipose tissues as
well as in the brain. Lack of Seipin gene, Bscl2, leads to not only severe lipid metabolic …

In recent decades, the role of tumor biomechanics on cancer cell behavior at the primary site
has been increasingly appreciated. However, the effect of primary tumor biomechanics on …

Activating mutations in the CTNNB1 gene encoding β-catenin are among the most
frequently observed oncogenic alterations in hepatocellular carcinoma (HCC). Profound …

Background The incidence of melanoma is increasing worldwide. Since metastatic
melanoma is highly aggressive, it is important to decipher all the biological aspects of …

Selenium and selenoproteins are closely related to melanoma progression. However, it is
unclear how SELENOK affects lipid metabolism, endoplasmic reticulum stress (ERS) …

Lipid droplets are fat storage organelles composed of a protein envelope and lipid‐rich core.
Regulation of this protein envelope underlies differential lipid droplet formation and function …

Maternal obesity and hyperglycemia are linked to an elevated risk for obesity, diabetes, and
steatotic liver disease in the adult offspring. To establish and validate a noninvasive …