NANOBODIES®: A Review of Generation, Diagnostics and Therapeutics
B Jin, S Odongo, M Radwanska, S Magez - International journal of …, 2023 - mdpi.com
NANOBODY®(a registered trademark of Ablynx NV) molecules (Nbs), also referred to as
single domain-based VHHs, are antibody fragments derived from heavy-chain only IgG …
single domain-based VHHs, are antibody fragments derived from heavy-chain only IgG …
Nanobodies as therapeutics: big opportunities for small antibodies
S Steeland, RE Vandenbroucke, C Libert - Drug discovery today, 2016 - Elsevier
Highlights•Nanobodies (Nbs) are camelid-derived single-domain antibodies.•Nbs have
powerful binding and inhibitory capacity with great therapeutic potential.•Nbs are used in …
powerful binding and inhibitory capacity with great therapeutic potential.•Nbs are used in …
Nanobody-based products as research and diagnostic tools
T De Meyer, S Muyldermans, A Depicker - Trends in biotechnology, 2014 - cell.com
Since the serendipitous discovery 20 years ago of bona fide camelid heavy-chain
antibodies, their single-domain antigen-binding fragments, known as VHHs or nanobodies …
antibodies, their single-domain antigen-binding fragments, known as VHHs or nanobodies …
Expression of recombinant antibodies
A Frenzel, M Hust, T Schirrmann - Frontiers in immunology, 2013 - frontiersin.org
Recombinant antibodies are highly specific detection probes in research, diagnostics, and
have emerged over the last two decades as the fastest growing class of therapeutic proteins …
have emerged over the last two decades as the fastest growing class of therapeutic proteins …
Research progress and applications of nanobody in human infectious diseases
Infectious diseases, caused by pathogenic microorganisms, are capable of affecting crises.
In addition to persistent infectious diseases such as malaria and dengue fever, the vicious …
In addition to persistent infectious diseases such as malaria and dengue fever, the vicious …
[HTML][HTML] Theranostics in immuno-oncology using nanobody derivatives
Q Lecocq, Y De Vlaeminck, H Hanssens… - Theranostics, 2019 - ncbi.nlm.nih.gov
Targeted therapy and immunotherapy have become mainstream in cancer treatment.
However, only patient subsets benefit from these expensive therapies, and often responses …
However, only patient subsets benefit from these expensive therapies, and often responses …
Expression of single-domain antibody in different systems
Y Liu, H Huang - Applied microbiology and biotechnology, 2018 - Springer
Camelid single-domain antibodies (sdAbs, VHHs, or Nanobodies®) are types of antibody
fragments that are composed of the heavy-chain variable domain only. These VHHs …
fragments that are composed of the heavy-chain variable domain only. These VHHs …
Nanobodies as molecular imaging probes
Camelidae derived single-domain antibodies (sdAbs), commonly known as nanobodies
(Nbs), are the smallest antibody fragments with full antigen-binding capacity. Owing to their …
(Nbs), are the smallest antibody fragments with full antigen-binding capacity. Owing to their …
A comprehensive comparison between camelid nanobodies and single chain variable fragments
Y Asaadi, FF Jouneghani, S Janani… - Biomarker Research, 2021 - Springer
By the emergence of recombinant DNA technology, many antibody fragments have been
developed devoid of undesired properties of natural immunoglobulins. Among them …
developed devoid of undesired properties of natural immunoglobulins. Among them …
Nanobodies as versatile tool for multiscale imaging modalities
M Erreni, T Schorn, F D'Autilia, A Doni - Biomolecules, 2020 - mdpi.com
Molecular imaging is constantly growing in different areas of preclinical biomedical
research. Several imaging methods have been developed and are continuously updated for …
research. Several imaging methods have been developed and are continuously updated for …