A long-standing mystery in the field of Polycomb and Trithorax regulation is how these
proteins, which are highly conserved between flies and mammals, can regulate several …

Arthropods and vertebrates inherited their Hox clusters from an ancestral cluster of at least
six genes already present in their last common ancestor, Urbilateria. Clustering and a …

Adult stem cell quiescence is critical to ensure regeneration while minimizing tumorigenesis.
Epigenetic regulation contributes to cell cycle control and differentiation, but few regulators …

Centromeres are characterized by the centromere-specific H3 variant CENP-A, which is
embedded in chromatin with a pattern characteristic of active transcription that is required for …

An ideal transgenic gene expression system is inducible, non-leaky, and well tolerated by
the target organism. While the former has been satisfactorily realized, leakiness and heavy …

Chromatin is a system of proteins, RNA, and DNA that interact with each other to organize
and regulate genetic information within eukaryotic nuclei. Chromatin proteins carry out …

Polycomb and Trithorax group proteins (PcG, TrxG) epigenetically regulate developmental
genes. These proteins bind with specific DNA elements, the Polycomb Response Element …

GAGA factor of Drosophila melanogaster (DmGAF) is a multifaceted transcription factor with
diverse roles in chromatin regulation. Recently, ThPOK/c-Krox was identified as its …

During the process of embryonic development in mammals, epigenetic modifications must
be erased and reconstructed. In particular, the trimethylation of histone 3 lysine 27 …

Background The cohesin complex consists of multiple core subunits that play critical roles in
mitosis and transcriptional regulation. The cohesin-associated protein Wapal plays a central …