Ubiquitin‐binding domains: Mechanisms of ubiquitin recognition and use as tools to investigate ubiquitin‐modified proteomes
Ubiquitin‐binding domains (UBDs) are modular units found within ubiquitin‐binding proteins
that mediate the non‐covalent recognition of (poly) ubiquitin modifications. A variety of …
that mediate the non‐covalent recognition of (poly) ubiquitin modifications. A variety of …
An integrated approach of NMR experiments and MD simulations visualizes structural dynamics of a cyclic multi‐domain protein
Cyclization can stabilize the structure of proteins, as previously demonstrated in single‐
domain proteins. Although Lys48‐linked polyubiquitin, a multi‐domain protein, is also …
domain proteins. Although Lys48‐linked polyubiquitin, a multi‐domain protein, is also …
Cyclization of ubiquitin chains reinforces their recognition by ZNF 216
T Sorada, E Walinda, D Morimoto - FEBS letters, 2024 - Wiley Online Library
Lys48‐linked ubiquitin chains, regulating proteasomal protein degradation, are known to
include cyclized forms. This cyclization hinders recognition by many downstream proteins by …
include cyclized forms. This cyclization hinders recognition by many downstream proteins by …
Molecular recognition and deubiquitination of cyclic K48-linked ubiquitin chains by OTUB1
Conjugation of K48-linked ubiquitin chains to intracellular proteins mainly functions as a
signal for proteasomal degradation. The conjugating enzyme E2-25K synthesizes not only …
signal for proteasomal degradation. The conjugating enzyme E2-25K synthesizes not only …
NMR explorations of biomolecular systems with rapid conformational exchanges
M Yagi-Utsumi, T Yamaguchi, R Kitahara… - Molecular Science of …, 2016 - Springer
Biomolecules such as proteins and oligosaccharides undergo dynamic conformational
exchanges, which are relevant to regulation of biologically functional processes as typified …
exchanges, which are relevant to regulation of biologically functional processes as typified …
[图书][B] Principles of complex polyubiquitin signaling, the structural basis for ubiquitin-ubistatin interactions, and novel assays for the characterization of deubiquitinases
MA Nakasone - 2013 - search.proquest.com
Ubiquitination is the most versatile and is certainly one of the most difficult post-translation
modifications to understand in eukaryotic life. In the process of ubiquitination the C-terminus …
modifications to understand in eukaryotic life. In the process of ubiquitination the C-terminus …