Fibroblast growth factors (FGF) are a family of ligands that bind to four different types of cell
surface receptor entitled, FGFR1, FGFR2, FGFR3 and FGFR4. These receptors differ in their …

Breast cancer (BC) is the most frequent form of malignancy and second only to lung cancer
as cause of deaths in women. Notwithstanding many progresses made in the field …

Dysregulation of Fibroblast Growth Factor Receptor (FGFR) signaling through amplifications,
mutations, and gene fusions has been implicated in a broad array of cancers (eg liver …

A high incidence of cancer has given rise to the development of more anti-tumor drugs. From
2015 to 2020, fifty-six new small-molecule anticancer drugs, divided into ten categories …

This work describes the design and synthesis of new hybrids of thienopyrimidine and
sulfonamides. The binding affinity of the prepared compounds to FGFR-1 enzyme and …

The ability of biomaterials to induce rapid vascular formation is critical in tissue regeneration.
Combining recombinant angiogenic growth factors with bioengineered constructs have …

The metastastic cascade is a complex process that is regulated at multiple levels in prostate
cancer (PCa). Recent evidence suggests that microRNAs (miRNAs) are involved in PCa …

Rogaratinib (BAY 1163877) is a highly potent and selective small‐molecule pan‐fibroblast
growth factor receptor (FGFR) inhibitor (FGFR1–4) for oral application currently being …

A bifunctional squaramide-catalyzed Michael/Michael cascade reaction for the construction
of five-membered spirooxindoles was developed. This reaction afforded the corresponding …

Suramin (SM), a drug for African sleeping sickness and river blindness therapy, has been
investigated in various clinical trials for cancer therapy. However, SM was eventually …