The neuroanatomical–functional paradox in spinal cord injury

K Fouad, PG Popovich, MA Kopp… - Nature Reviews …, 2021 - nature.com
Although lesion size is widely considered to be the most reliable predictor of outcome after
CNS injury, lesions of comparable size can produce vastly different magnitudes of functional …

From basics to clinical: a comprehensive review on spinal cord injury

NA Silva, N Sousa, RL Reis, AJ Salgado - Progress in neurobiology, 2014 - Elsevier
Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

Robust and multifunctional nanoparticles assembled from natural polyphenols and metformin for efficient spinal cord regeneration

T Yuan, T Wang, J Zhang, P Liu, J Xu, Z Gu, J Xu, Y Li - ACS nano, 2023 - ACS Publications
The treatment of spinal cord injury (SCI) remains unsatisfactory owing to the complex
pathophysiological microenvironments at the injury site and the limited regenerative …

Carrier-free nanodrug based on Co-assembly of methylprednisolone dimer and rutin for combined treatment of spinal cord injury

H Wang, F Lin, Y Wu, W Guo, X Chen, C Xiao… - ACS nano, 2023 - ACS Publications
Spinal cord injury (SCI), which is characterized by excessive inflammatory cell infiltration
and accumulation of oxidative substance, would severely impede neurological functional …

RETRACTED ARTICLE: SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion

X Wang, W Xu, G Hu, S Xia, Z Sun, Z Liu… - Cellular & molecular …, 2023 - nature.com
The authors have retracted this article [1]. After the publication of this article, it came to the
authors attention that in order to support the conclusions of the study, the authors should …

3D bioprinted neural tissue constructs for spinal cord injury repair

X Liu, M Hao, Z Chen, T Zhang, J Huang, J Dai… - Biomaterials, 2021 - Elsevier
Abstract Three-dimensional (3D) bioprinting has emerged as a promising approach to
fabricate living neural constructs with anatomically accurate complex geometries and spatial …

Intranasal delivery of mesenchymal stem cell derived exosomes loaded with phosphatase and tensin homolog siRNA repairs complete spinal cord injury

S Guo, N Perets, O Betzer, S Ben-Shaul, A Sheinin… - ACS …, 2019 - ACS Publications
Individuals with spinal cord injury (SCI) usually suffer from permanent neurological deficits,
while spontaneous recovery and therapeutic efficacy are limited. Here, we demonstrate that …

Highly permeable DNA supramolecular hydrogel promotes neurogenesis and functional recovery after completely transected spinal cord injury

T Yuan, Y Shao, X Zhou, Q Liu, Z Zhu… - Advanced …, 2021 - Wiley Online Library
Regeneration after severe spinal cord injury cannot occur naturally in mammals.
Transplanting stem cells to the injury site is a highly promising method, but it faces many …

Integrating hydrogels manipulate ECM deposition after spinal cord injury for specific neural reconnections via neuronal relays

Z Tan, L Xiao, J Ma, K Shi, J Liu, F Feng, P Xie… - Science …, 2024 - science.org
A bioinspired hydrogel composed of hyaluronic acid-graft-dopamine (HADA) and a designer
peptide HGF-(RADA) 4-DGDRGDS (HRR) was presented to enhance tissue integration …

Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury

H Fan, HB Tang, Z Chen, HQ Wang, L Zhang… - Journal of …, 2020 - Springer
Background Spinal cord injury (SCI) favors a persistent pro-inflammatory macrophages/
microglia-mediated response with only a transient appearance of anti-inflammatory …