Neurons are markedly compartmentalized, which makes them reliant on axonal transport to
maintain their health. Axonal transport is important for anterograde delivery of newly …

The use of the diffusion tensor imaging (DTI) is rapidly growing in the neuroimaging field.
Nevertheless, rigorously performed quantitative validation of DTI pathologic metrics remains …

Summary Huntington's disease (HD), a devastating neurodegenerative disorder, strongly
affects the corticostriatal network, but the contribution of pre-and postsynaptic neurons in the …

Aging constitutes the main risk factor for the development of neurodegenerative diseases.
This represents a major health issue worldwide that is only expected to escalate due to the …

Huntington's disease (HD) is a neurodegenerative disease caused by an expanded CAG
repeat in the Huntingtin (HTT) gene. Induced pluripotent stem cell (iPSC) models of HD …

The human motor cortex comprises a microcircuit of five interconnected layers with different
cell types. In this Review, we use a layer-specific and cell-specific approach to integrate …

Neurons affected in a wide variety of unrelated adult-onset neurodegenerative diseases
(AONDs) typically exhibit a “dying back” pattern of degeneration, which is characterized by …

Tauopathies are a diverse group of diseases featuring progressive dying-back
neurodegeneration of specific neuronal populations in association with accumulation of …

Non-Gaussian (anomalous) diffusion is wide spread in biological tissues where its effects
modulate chemical reactions and membrane transport. When viewed using magnetic …

Synaptic dysfunction and altered calcium homeostasis in the brain is common to many
neurodegenerative disorders. Among these, Huntington disease (HD), which is inherited in …