Covering: up to 2015 This review summarises the accumulated knowledge about
characterised bacterial terpene cyclases. The structures of identified products and of …

Covering: up to mid-2020 Terpenoids, also called isoprenoids, are the largest and most
structurally diverse family of natural products. Found in all domains of life, there are over 80 …

Covering: up to July 2023 Terpene cyclases (TCs) catalyze some of the most complicated
reactions in nature and are responsible for creating the skeletons of more than 95 000 …

Mycobacterium tuberculosis is an extremely successful pathogen that demonstrates the
capacity to modulate its host both at the cellular and tissue levels. At the cellular level, the …

The pathogen Mycobacterium tuberculosis (Mtb), causing tuberculosis disease, features an
extraordinary thick cell envelope, rich in Mtb-specific lipids, glycolipids, and glycans. These …

Although nontuberculous mycobacteria (NTM) are considered opportunistic infections,
incidence and prevalence of NTM infection are increasing worldwide becoming a major …

The structures and mechanism of action of many terpene cyclases are known, but no
structures of diterpene cyclases have yet been reported. Here, we propose structural models …

Tuberculosis (TB) is a severe infectious disease worldwide. The increasing emergence of
drug‐resistant Mycobacterium tuberculosis (Mtb) has markedly hampered TB control …

Ancient protozoan phagocytes and modern professional phagocytes of metazoans, such as
macrophages, employ evolutionarily conserved mechanisms to kill microbes. These …

Mycobacterium tuberculosis (Mtb) is the world's most deadly pathogen. Unlike less virulent
mycobacteria, Mtb produces 1-tuberculosinyladenosine (1-TbAd), an unusual terpene …