lncRNA-microRNA axis in cancer drug resistance: particular focus on signaling pathways

RO Saleh, MTS Al-Ouqaili, E Ali, S Alhajlah… - Medical Oncology, 2024 - Springer
Cancer drug resistance remains a formidable challenge in modern oncology, necessitating
innovative therapeutic strategies. The convergence of intricate regulatory networks involving …

Recent clinical advances on long non-coding RNAs in triple-negative breast cancer

DD Singh, HJ Lee, DK Yadav - Cells, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) is a more aggressive type of breast cancer due to its
heterogeneity and complex molecular mechanisms. TNBC has a high risk for metastasis …

The long noncoding RNA HNF1A-AS1 with dual functions in the regulation of cytochrome P450 3A4

Y Wang, P Wang, Q Wang, S Chen, X Wang… - Biochemical …, 2024 - Elsevier
Abstract Cytochrome P450 3A4 (CYP3A4) is the most important and abundant drug-
metabolizing enzyme in the human liver. Inter-individual differences in the expression and …

lncRNAs'p potential roles in the pathogenesis of cancer via interacting with signaling pathways; special focus on lncRNA-mediated signaling dysregulation in lung …

SI Shelash, IA Shabeeb, I Ahmad, HM Saleem… - Medical Oncology, 2024 - Springer
Lung cancer ranks among the most lethal types of cancer globally, with a high occurrence
and fatality rate. The spread of cancer to other parts of the body, known as metastasis, is the …

[HTML][HTML] A senescence-related lncRNA signature predicts prognosis and reflects immune landscape in HNSCC

L Chen, J Lin, Y Wen, B Lan, J Xiong, Y Fu, Y Chen… - Oral Oncology, 2024 - Elsevier
Abstract Objective Long noncoding RNAs (lncRNAs) regulate cancer cell senescence in
many cancers. However, their specific involvement in head and neck squamous cell …

The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications

JMC Silva, EB Teixeira, RMS Mourão… - Frontiers in …, 2023 - frontiersin.org
Gastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide.
Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial …

Tumor-derived lncRNAs; Behind-the-scenes mediators that modulate the immune system and play a role in cancer pathogenesis

SIS Al-Hawary, RO Saleh, SG Taher, SM Ahmed… - … -Research and Practice, 2024 - Elsevier
Having been involved in complex cellular regulatory networks and cell-to-cell
communications, non-coding RNAs (lncRNAs) have become functional carriers that transmit …

Exploring potential roles of long non-coding RNAs in cancer immunotherapy: a comprehensive review

A Arshi, E Mahmoudi, F Raeisi… - Frontiers in …, 2024 - frontiersin.org
Cancer treatment has long been fraught with challenges, including drug resistance,
metastasis, and recurrence, making it one of the most difficult diseases to treat effectively …

[HTML][HTML] RNA epigenetics in pulmonary diseases: Insights into methylation modification of lncRNAs in lung cancer

J Jiang, M Duan, Z Wang, Y Lai, C Zhang… - Biomedicine & …, 2024 - Elsevier
Long non-coding RNAs (lncRNAs) are pivotal controllers of gene expression through
epigenetic mechanisms, Methylation, a prominent area of study in epigenetics, significantly …

Remodeling of tumour microenvironment: strategies to overcome therapeutic resistance and innovate immunoengineering in triple-negative breast cancer

DD Singh, S Haque, Y Kim, I Han… - Frontiers in …, 2024 - frontiersin.org
Triple-negative breast cancer (TNBC) stands as the most complex and daunting subtype of
breast cancer affecting women globally. Regrettably, treatment options for TNBC remain …