Advancing preclinical models of psychiatric disorders with human brain organoid cultures

TA Dixon, AR Muotri - Molecular Psychiatry, 2023 - nature.com
Psychiatric disorders are often distinguished from neurological disorders in that the former
do not have characteristic lesions or findings from cerebrospinal fluid …

Human mini brains and spinal cords in a dish: Modeling strategies, current challenges, and prospective advances

S Kofman, N Mohan, X Sun, L Ibric… - Journal of Tissue …, 2022 - journals.sagepub.com
Engineered three-dimensional (3D) in vitro and ex vivo neural tissues, also known as “mini
brains and spinal cords in a dish,” can be derived from different types of human stem cells …

Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes

Y Wang, S Chiola, G Yang, C Russell… - Nature …, 2022 - nature.com
Human telencephalon is an evolutionarily advanced brain structure associated with many
uniquely human behaviors and disorders. However, cell lineages and molecular pathways …

Gene–environment interactions in developmental neurotoxicity: a case study of synergy between chlorpyrifos and CHD8 knockout in human brainspheres

S Modafferi, X Zhong, A Kleensang… - Environmental …, 2021 - ehp.niehs.nih.gov
Background: Autism spectrum disorder (ASD) is a major public health concern caused by
complex genetic and environmental components. Mechanisms of gene–environment (G× E) …

Brain organoids as model systems for genetic neurodevelopmental disorders

S Baldassari, I Musante, M Iacomino, F Zara… - Frontiers in Cell and …, 2020 - frontiersin.org
Neurodevelopmental disorders (NDDs) are a group of disorders in which the development
of the central nervous system (CNS) is disturbed, resulting in different neurological and …

Recent developments in autism genetic research: A scientometric review from 2018 to 2022

M Lim, A Carollo, D Dimitriou, G Esposito - Genes, 2022 - mdpi.com
Genetic research in Autism Spectrum Disorder (ASD) has progressed tremendously in
recent decades. Dozens of genetic loci and hundreds of alterations in the genetic sequence …

Functional bioengineered models of the central nervous system

N Rouleau, NJ Murugan, DL Kaplan - Nature Reviews Bioengineering, 2023 - nature.com
The functional complexity of the central nervous system (CNS) is unparalleled in living
organisms. Its nested cells, circuits and networks encode memories, move bodies and …

[HTML][HTML] Screening platforms for genetic epilepsies—zebrafish, iPSC-derived neurons, and organoids

A Shcheglovitov, RT Peterson - Neurotherapeutics, 2021 - Elsevier
Recent advances in molecular and cellular engineering, such as human cell
reprogramming, genome editing, and patient-specific organoids, have provided …

[HTML][HTML] Identification of neurodevelopmental organization of the cell populations of juvenile Huntington's disease using dorso-ventral HD organoids and HD mouse …

K Świtońska-Kurkowska, J Kubiś, J Delimata-Raczek… - eLife, 2025 - elifesciences.org
Huntington's disease (HD) is a polyglutamine neurodegenerative disease involving
pathogenesis within the striatum and cerebral cortex and a neurodevelopmental component …

Evaluating the regulatory function of non‐coding autism‐associated single nucleotide polymorphisms on gene expression in human brain tissue

K Pugsley, A Namipashaki, MA Bellgrove… - Autism …, 2024 - Wiley Online Library
Common variants account for most of the estimated heritability associated with autism
spectrum disorder (autism). Although several replicable single nucleotide polymorphisms …