A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and
accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …

Clinicopathologic correlation studies are critically important for the field of Alzheimer disease
(AD) research. Studies on human subjects with autopsy confirmation entail numerous …

Mechanisms of protein homeostasis are crucial for overseeing the clearance of misfolded
and toxic proteins over the lifetime of an organism, thereby ensuring the health of neurons …

Recent demonstrations that the secretion, uptake, and interneuronal transfer of tau can be
modulated by disease-associated tau modifications suggest that secretion may be an …

In neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD)
and prion diseases, deposits of aggregated disease-specific proteins are found. Oligomeric …

Cellular deposition of protein aggregates, one of the hallmarks of neurodegeneration,
disrupts cellular functions and leads to neuronal death. Mutations, posttranslational …

Parkinson's disease (PD) is a common neurodegenerative disorder with prominent loss of
nigro‐striatal dopaminergic neurons. The resultant dopamine (DA) deficiency underlies the …

Alzheimer's disease (AD) is the most common neurodegenerative disease affecting more
than 50 million people worldwide. The pathology of this multifactorial disease is primarily …

Alzheimer's and Parkinson's diseases are the most common neurodegenerative diseases.
They are characterized by protein aggregates and so can be considered as prion-like …

Metal ions, mainly copper, zinc and iron, have been involved in several processes
associated with the etiology of Alzheimer disease (AD). Amyloid deposits found in AD …