Aging happens to all of us as we live. Thanks to the improved living standard and discovery
of life-saving medicines, our life expectancy has increased substantially across the world in …

The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

Twenty-nine years following the breakthrough discovery that a single-gene mutation of daf-2
doubles Caenorhabditis elegans lifespan, it remains unclear where this insulin/IGF-1 …

The mechanisms that extend lifespan in humans are poorly understood. Here we show that
extended longevity in humans is associated with a distinct transcriptome signature in the …

Ageing is a result of gradual and overall functional deteriorations across the body; however,
it is unknown whether an individual tissue primarily works to mediate the ageing progress …

The ability to ensure proteostasis is critical for maintaining proper cell function and
organismal viability but is mitigated by aging. We analyzed the role of the endoplasmic …

The life span of C. elegans can be increased via reduced function of the mitochondria;
however, the extent to which mitochondrial alteration in a single, distinct tissue may …

Phosphorylated lipids are produced at cellular membranes during signaling events and
contribute to the recruitment and activation of various signaling components. The role of …

Ageing is a fundamental, unsolved mystery in biology. DAF-16, a FOXO-family transcription
factor, influences the rate of ageing of Caenorhabditis elegans in response to insulin/insulin …

The progressive loss of muscle strength during aging is a common degenerative event of
unclear pathogenesis. Although muscle functional decline precedes age-related changes in …