One of the key challenges in cancer research is how to effectively kill cancer cells while
leaving the healthy cells intact. Cancer cells often have defects in cell death executioner …

Terpenoids, the most abundant compounds in natural products, are a set of important
secondary metabolites in plants with diverse structures. Terpenoids play key roles in plant …

Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria
and related symptomes (fever, chills). Its active ingredient, artemisinin (ARS), has been …

Since its discovery in 2012, ferroptosis has been well characterized by the accumulation of
lipid peroxides due to the failure of glutathione-dependent antioxidant defenses. It is known …

The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …

Ferroptosis is a novel type of programmed cell death, characterized by a dysregulated iron
metabolism and accumulation of lipid peroxides. It features the alteration of mitochondria …

Activation of hepatic stellate cells (HSCs) is a central event in the development of liver
fibrosis, and the elimination of activated HSCs is considered to be an effective anti-fibrotic …

Due to their remarkable parasitocidal activity, artemisinins represent the key components of
first-line therapies against Plasmodium falciparum malaria. However, the decline in efficacy …

Emergence and spread of resistance in Plasmodium falciparum to the frontline treatment
artemisinin-based combination therapies (ACTs) in the epicenter of multidrug resistance of …

Ferroptosis is a type of programmed cell death that depends on iron and is characterized by
the accumulation of lipid peroxides. In the present study, we investigated the nature of the …