Definition and treatment of arrhythmogenic cardiomyopathy: an updated expert panel report

PM Elliott, A Anastasakis, A Asimaki… - European journal of …, 2019 - Wiley Online Library
It is 35 years since the first description of arrhythmogenic right ventricular cardiomyopathy
(ARVC) and more than 20 years since the first reports establishing desmosomal gene …

The role of genetics in cardiovascular disease: arrhythmogenic cardiomyopathy

CA James, P Syrris, JP Van Tintelen… - European heart …, 2020 - academic.oup.com
Arrhythmogenic cardiomyopathy (ACM) is a heritable cardiomyopathy characterized by
frequent ventricular arrhythmias and progressive ventricular dysfunction. Risk of sudden …

2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy

JA Towbin, WJ McKenna, DJ Abrams, MJ Ackerman… - Heart rhythm, 2019 - Elsevier
Arrhythmogenic cardiomyopathy (ACM) is an arrhythmogenic disorder of the myocardium
not secondary to ischemic, hypertensive, or valvular heart disease. ACM incorporates a …

International evidence based reappraisal of genes associated with arrhythmogenic right ventricular cardiomyopathy using the clinical genome resource framework

CA James, JDH Jongbloed… - Circulation: Genomic …, 2021 - Am Heart Assoc
Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited
disease characterized by ventricular arrhythmias and progressive ventricular dysfunction …

Insights into genetics and pathophysiology of arrhythmogenic cardiomyopathy

B Gerull, A Brodehl - Current Heart Failure Reports, 2021 - Springer
Abstract Purpose of Review Arrhythmogenic cardiomyopathy (ACM) is a genetic disease
characterized by life-threatening ventricular arrhythmias and sudden cardiac death (SCD) in …

Next-generation sequencing gene panels in Inheritable cardiomyopathies and channelopathies: prevalence of pathogenic variants and variants of unknown …

C Mazzaccara, R Lombardi, B Mirra, F Barretta… - Biomolecules, 2022 - mdpi.com
The diffusion of next-generation sequencing (NGS)-based approaches allows for the
identification of pathogenic mutations of cardiomyopathies and channelopathies in more …

Human induced pluripotent stem-cell-derived cardiomyocytes as models for genetic cardiomyopathies

A Brodehl, H Ebbinghaus, MA Deutsch… - International journal of …, 2019 - mdpi.com
In the last few decades, many pathogenic or likely pathogenic genetic mutations in over
hundred different genes have been described for non-ischemic, genetic cardiomyopathies …

Understanding arrhythmogenic cardiomyopathy: advances through the use of human pluripotent stem cell models

CJ Chua, J Morrissette-McAlmon, L Tung, KR Boheler - Genes, 2023 - mdpi.com
Cardiomyopathies (CMPs) represent a significant healthcare burden and are a major cause
of heart failure leading to premature death. Several CMPs are now recognized to have a …

Understanding the molecular basis of cardiomyopathy

ML Bang, J Bogomolovas… - American Journal of …, 2022 - journals.physiology.org
Inherited cardiomyopathies are a major cause of mortality and morbidity worldwide and can
be caused by mutations in a wide range of proteins located in different cellular …

Genetic animal models for arrhythmogenic cardiomyopathy

B Gerull, A Brodehl - Frontiers in Physiology, 2020 - frontiersin.org
Arrhythmogenic cardiomyopathy has been clinically defined since the 1980s and causes
right or biventricular cardiomyopathy associated with ventricular arrhythmia. Although it is a …