[HTML][HTML] Synaptic genes and neurodevelopmental disorders: From molecular mechanisms to developmental strategies of behavioral testing

C Michetti, A Falace, F Benfenati, A Fassio - Neurobiology of Disease, 2022 - Elsevier
Synaptopathies are a class of neurodevelopmental disorders caused by modification in
genes coding for synaptic proteins. These proteins oversee the process of …

Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes

KJ Peall, MJ Owen, J Hall - Nature Reviews Neurology, 2024 - nature.com
Understanding rare genetic brain disorders with overlapping neurological and psychiatric
phenotypes is of increasing importance given the potential for developing disease models …

Synaptopathies in developmental and epileptic encephalopathies: A focus on pre-synaptic dysfunction

G Spoto, G Valentini, MC Saia, A Butera… - Frontiers in …, 2022 - frontiersin.org
The proper connection between the pre-and post-synaptic nervous cells depends on any
element constituting the synapse: the pre-and post-synaptic membranes, the synaptic cleft …

Syntabulin regulates neuronal excitation/inhibition balance and epileptic seizures by transporting syntaxin 1B

P Ke, J Gu, J Liu, Y Liu, X Tian, Y Ma, Y Meng… - Cell Death …, 2023 - nature.com
Epilepsy is a widespread neurological disorder affecting more than 65 million people, but
the mechanisms of epilepsy remains unknown. Abnormal synaptic transmission has a …

Epileptic phenotypes associated with SNAREs and related synaptic vesicle exocytosis machinery

E Cali, C Rocca, V Salpietro, H Houlden - Frontiers in Neurology, 2022 - frontiersin.org
SNAREs (soluble N-ethylmaleimide sensitive factor attachment protein receptor) are an
heterogeneous family of proteins that, together with their key regulators, are implicated in …

Inflammation as a target for the treatment of fever-associated epilepsy in zebrafish larvae

W Liang, J Wang, J Sui, F Yun, Y Shen, J Zhou… - International …, 2023 - Elsevier
Inflammation is considered to be involved in epileptogenesis. However, the relationship
between fever and inflammation as well as the mechanisms of fever in the occurrence and …

Dual lanthanide Complexes-Loaded ratiometric nanothermometer for elucidating intracellular variations of temperature and calcium transport

N Yin, Y Yu, X Wang, Y Shu, J Wang - Chemical Engineering Journal, 2024 - Elsevier
Herein, we report a ratiometric nanothermometer to study the correlation of heat/temperature
and intracellular calcium transport. Firstly, poly (methyl methacrylate)-based copolymeric …

Similarity and diversity of presynaptic molecules at neuromuscular junctions and central synapses

K Takikawa, H Nishimune - Biomolecules, 2022 - mdpi.com
Synaptic transmission is essential for controlling motor functions and maintaining brain
functions such as walking, breathing, cognition, learning, and memory. Neurotransmitter …

Repetitive pulsed-wave ultrasound stimulation suppresses neural activity by modulating ambient GABA levels via effects on astrocytes

T Mishima, K Komano, M Tabaru, T Kofuji… - Frontiers in Cellular …, 2024 - frontiersin.org
Ultrasound is highly biopermeable and can non-invasively penetrate deep into the brain.
Stimulation with patterned low-intensity ultrasound can induce sustained inhibition of neural …

Chronic social instability stress differentially affects the behavior and the transcriptome of the anterodorsal bed nucleus of the stria terminalis between male and female …

TJ Degroat, SE Paladino, K Denney, KM Moran… - bioRxiv, 2025 - biorxiv.org
Stress can be broken down into systemic and processive stressors with processive stressors
requiring higher limbic processing. These are also often called social stressors as they …