BACKGROUND In humans, inadequate trophoblast invasion into the decidua is associated
with the 'great obstetrical syndromes' which include pre-eclampsia, foetal growth restriction …

Embryo implantation in humans is interstitial, meaning the entire conceptus embeds in the
endometrium before the placental trophoblast invades beyond the uterine mucosa into the …

Decidual remodelling of midluteal endometrium leads to a short implantation window after
which the uterine mucosa either breaks down or is transformed into a robust matrix that …

Successful establishment of pregnancy requires adhesion of an embryo to the endometrium
and subsequent invasion into the maternal tissue. Abnormalities in this critical process of …

Background The human endometrium undergoes recurring cycles of growth, differentiation,
and breakdown in response to sex hormones. Dysregulation of epithelial-stromal …

The endometrium is the secretory lining of the uterus that undergoes dynamic changes
throughout the menstrual cycle in preparation for implantation and a pregnancy. Recently …

The emergence of collagen I in vertebrates resulted in a dramatic increase in the stiffness of
the extracellular environment, supporting long-range force propagation and the …

Drug and chemical development along with safety tests rely on the use of numerous clinical
models. This is a lengthy process where animal testing is used as a standard for pre-clinical …

Articular cartilage is a highly specialised connective tissue of diarthrodial joints which
provides a smooth, lubricated surface for joint articulation and plays a crucial role in the …

STUDY QUESTION How do elastic matrisome components change during the lifetime of the
human ovary? SUMMARY ANSWER The deposition and remodeling of mechanical …