Microbiome and immunological interactions
D Kelly, IE Mulder - Nutrition reviews, 2012 - academic.oup.com
The healthy human gut supports a complex and diverse microbiota, dominated by bacterial
phylotypes belonging to Bacteroidetes and Firmicutes. In the inflamed gut, overall diversity …
phylotypes belonging to Bacteroidetes and Firmicutes. In the inflamed gut, overall diversity …
[HTML][HTML] Ontology mapping for semantically enabled applications
Highlights•Ontology mapping enables data analytics through interoperability and
integration.•Mapping between ontologies expands coverage across large domains such as …
integration.•Mapping between ontologies expands coverage across large domains such as …
Integrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia
Inappropriate localization of proteins can interfere with normal cellular function and drive
tumor development. To understand how this contributes to the development of acute myeloid …
tumor development. To understand how this contributes to the development of acute myeloid …
Selection of personalized patient therapy through the use of knowledge-based computational models that identify tumor-driving signal transduction pathways
Increasing knowledge about signal transduction pathways as drivers of cancer growth has
elicited the development of “targeted drugs,” which inhibit aberrant signaling pathways. They …
elicited the development of “targeted drugs,” which inhibit aberrant signaling pathways. They …
Fatigue is associated with inflammation in patients with head and neck cancer before and after intensity-modulated radiation therapy
Patients with head and neck cancer (HNC) receiving intensity-modulated radiation therapy
(IMRT) have particularly high rates of fatigue, and pre-and post-radiotherapy fatigue are …
(IMRT) have particularly high rates of fatigue, and pre-and post-radiotherapy fatigue are …
Association of childhood trauma with fatigue, depression, stress, and inflammation in breast cancer patients undergoing radiotherapy
Background This pilot study examined whether breast cancer patients with childhood trauma
exhibit increased fatigue, depression, and stress in association with inflammation as a result …
exhibit increased fatigue, depression, and stress in association with inflammation as a result …
[HTML][HTML] Assessment of functional phosphatidylinositol 3-kinase pathway activity in cancer tissue using forkhead box-O target gene expression in a knowledge-based …
H Van Ooijen, M Hornsveld, C Dam-de Veen… - The American journal of …, 2018 - Elsevier
The phosphatidylinositol 3-kinase (PI3K) pathway is commonly activated in cancer. Tumors
are potentially sensitive to PI3K pathway inhibitors, but reliable diagnostic tests that assess …
are potentially sensitive to PI3K pathway inhibitors, but reliable diagnostic tests that assess …
Predictors of depression in breast cancer patients treated with radiation: role of prior chemotherapy and nuclear factor kappa B
BACKGROUND Depression is common during and after breast cancer treatment. However,
the role of specific therapeutic modalities and related biologic mechanisms remains unclear …
the role of specific therapeutic modalities and related biologic mechanisms remains unclear …
Cell cycle networks link gene expression dysregulation, mutation, and brain maldevelopment in autistic toddlers
T Pramparo, MV Lombardo, K Campbell… - Molecular systems …, 2015 - embopress.org
Genetic mechanisms underlying abnormal early neural development in toddlers with Autism
Spectrum Disorder (ASD) remain uncertain due to the impossibility of direct brain gene …
Spectrum Disorder (ASD) remain uncertain due to the impossibility of direct brain gene …
Transcriptional signatures related to glucose and lipid metabolism predict treatment response to the tumor necrosis factor antagonist infliximab in patients with …
The tumor necrosis factor (TNF) antagonist infliximab was recently found to reduce
depressive symptoms in patients with increased baseline inflammation as reflected by a …
depressive symptoms in patients with increased baseline inflammation as reflected by a …