Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood
flow and also has important roles in intracellular signaling in neurons from the regulation of …

S-Nitrosylation is a redox-mediated posttranslational modification that regulates protein
function via covalent reaction of nitric oxide (NO)-related species with a cysteine thiol group …

Despite decades of speculation that inhibiting endogenous insulin degradation might treat
type-2 diabetes,, and the identification of IDE (insulin-degrading enzyme) as a diabetes …

After decades of research and clinical trials there is still no cure for Alzheimer's disease
(AD). While impaired clearance of amyloid beta (Aβ) peptides is considered as one of the …

ERAP1 trims antigen precursors to fit into MHC class I proteins. To fulfill this function, ERAP1
has unique substrate preferences, trimming long peptides but sparing shorter ones. To …

Abstract Rationale Intracerebroventricular (ICV) streptozotocin (STZ) mimics sporadic
Alzheimer's disease (SAD) characterized by tau pathology and neurodegeneration arising …

Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed
metalloprotease that degrades insulin and several other intermediate-size peptides. For …

Macrophage inflammatory protein‐1 (MIP‐1), MIP‐1α (CCL3) and MIP‐1β (CCL4) are
chemokines crucial for immune responses towards infection and inflammation. Both MIP‐1α …

The insulin-degrading enzyme (IDE) degrades amyloidogenic proteins such as Amyloid β
(Αβ) and Islet Amyloid Polypeptide (IAPP), ie peptides associated with Alzheimer's disease …

Insulin-degrading enzyme (IDE) selectively degrades peptides, such as insulin, amylin, and
amyloid β (Aβ) that form toxic aggregates, to maintain proteostasis. IDE defects are linked to …