Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

Abstract Insulin-like growth factor-1 (IGF-1), a pleiotropic polypeptide, plays an essential role
in CNS development and maturation. Glucagon-like peptide-1 (GLP-1) is an endogenous …

While the insulin receptor (IR) was found in the CNS decades ago, the brain was long
considered to be an insulin‐insensitive organ. This view is currently revisited, given …

Autism spectrum disorder (ASD) affecting about 1% of all children is associated, in addition
to complex genetic factors, with a variety of prenatal, perinatal, and postnatal etiologies. In …

Despite the remarkable number of scientific breakthroughs of the last 100 years, the
treatment of neurodevelopmental disorders (eg, autism spectrum disorder, intellectual …

Recent data support the use of behavioural and psychological interventions for social
communication and anxiety in ASD; data are more limited regarding pharmacotherapy for …

Drug studies on Rett syndrome (RTT) have drastically increased over the past few decades.
This review aims to provide master data on bench-to-bedside drug studies involving RTT. A …

Background Autism spectrum disorder (ASD) is a highly heterogeneous
neurodevelopmental disorder with a complex underlying genetic architecture. There are …

Objective To measure the efficacy of mecasermin (recombinant human insulin‐like growth
factor 1, rh IGF‐1), for treating symptoms of Rett syndrome (RTT) in a pediatric population …

Abstract Background Phelan-McDermid syndrome (PMS) is caused by haploinsufficiency of
the SHANK3 gene and is characterized by global developmental delays and autism …