Hypoxic pulmonary vasoconstriction

JT Sylvester, LA Shimoda, PI Aaronson… - Physiological …, 2012 - journals.physiology.org
It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

Presynaptic sensor and silencer of peptidergic transmission reveal neuropeptides as primary transmitters in pontine fear circuit

DI Kim, S Park, S Park, M Ye, JY Chen, SJ Kang… - Cell, 2024 - cell.com
Neurons produce and release neuropeptides to communicate with one another. Despite
their importance in brain function, circuit-based mechanisms of peptidergic transmission are …

Pulmonary vascular innervation and its role in responses to hypoxia: size matters!

W Kummer - Proceedings of the American Thoracic Society, 2011 - atsjournals.org
The pulmonary vasculature is innervated by specific subsets of sympathetic,
parasympathetic, and sensory nerve fibers. In contrast to most other organs, innervation …

High-frequency activation of nucleus accumbens D1-MSNs drives excitatory potentiation on D2-MSNs

TC Francis, H Yano, TG Demarest, H Shen, A Bonci - Neuron, 2019 - cell.com
Subtypes of nucleus accumbens medium spiny neurons (MSNs) promote dichotomous
outcomes in motivated behaviors. However, recent reports indicate enhancing activity of …

Respiratory modulated sympathetic activity: a putative mechanism for developing vascular resistance?

LJB Briant, EL O'Callaghan… - The journal of …, 2015 - Wiley Online Library
Key points Sympathetic activity exhibits respiratory modulation that is amplified in
hypertensive rats. Respiratory modulated sympathetic activity produces greater changes in …

Hindered submicron mobility and long‐term storage of presynaptic dense‐core granules revealed by single‐particle tracking

BA Scalettar, C Jacobs, A Fulwiler… - Developmental …, 2012 - Wiley Online Library
Dense‐core granules (DCGs) are organelles found in neuroendocrine cells and neurons
that house, transport, and release a number of important peptides and proteins. In neurons …

[HTML][HTML] Novel genetically encoded tools for imaging or silencing neuropeptide release from presynaptic terminals in vivo

DI Kim, S Park, M Ye, JY Chen, J Jhang, AC Hunker… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Neurons produce and release neuropeptides to communicate with one another. Despite
their profound impact on critical brain functions, circuit-based mechanisms of peptidergic …

Encoding opposing valences through frequency-dependent transmitter switching in single peptidergic neurons

DI Kim, SJ Kang, J Jhang, YS Jo, S Park, M Ye… - bioRxiv, 2024 - biorxiv.org
Peptidergic neurons often co-express fast transmitters and neuropeptides in separate
vesicles with distinct release properties. However, the release dynamics of each transmitter …

Neurotransmitter segregation: functional and plastic implications

C Sámano, F Cifuentes, MA Morales - Progress in neurobiology, 2012 - Elsevier
Synaptic cotransmission is the ability of neurons to use more than one transmitter to convey
synaptic signals. Cotransmission was originally described as the presence of a classic …

Long-term potentiation in mammalian autonomic ganglia: an inclusive proposal of a calcium-dependent, trans-synaptic process

F Cifuentes, ER Arias, MA Morales - Brain Research Bulletin, 2013 - Elsevier
Ganglionic synapses have the capability to express long-term potentiation (gLTP) after
application of a brief high-frequency stimulus. It has been suggested a possible role of gLTP …