Given that hypoxia is a persistent physiological feature of many different solid tumors and a
key driver for cancer malignancy, it is thought to be a major target in cancer treatment …

Proper progression throughout the cell division cycle depends on the expression level of a
family of proteins known as cyclins, and the subsequent activation of cyclin-dependent …

We have conducted a detailed transcriptomic, proteomic and phosphoproteomic analysis of
CDK8 and its paralog CDK19, alternative enzymatic components of the kinase module …

Evidence suggests that cell cycle activation plays a role in the pathophysiology of
neurodegenerative diseases. Alzheimer's disease is a progressive, terminal …

Abstract Cyclin Dependent Kinases (CDKs) represent a large family of serine/threonine
protein kinases that become active upon binding to a Cyclin regulatory partner. CDK/cyclin …

The cell wall integrity (CWI) MAPK pathway of budding yeast Saccharomyces cerevisiae is
specialized in responding to cell wall damage, but ongoing research shows that it …

Simple Summary Mitochondria are the core energy-generating units found within a cell. In
addition, mitochondria harbor molecular factors that are essential, upon their release from …

Regulation of cell division is orchestrated by cyclins, which bind and activate their catalytic
workmates, the cyclin-dependent kinases (CDKs). Cyclins have been traditionally defined by …

Abstract Cyclin-dependent kinase 8 (CDK8) plays an momentous role in transcription
regulation by forming kinase module or transcription factor phosphorylation. A large number …

Cell-signaling pathways are essential for cells to respond and adapt to changes in their
environmental conditions. The cell-wall integrity (CWI) pathway of Saccharomyces …