This comprehensive review surveys developments over the past decade in the field of
naphthalene diimides (NDIs). It explores their application toward: supramolecular chemistry; …

DNA and RNA can fold into a variety of alternative conformations. In recent years, a
particular nucleic acid structure was discussed to play a role in malignant transformation and …

Guanine-rich DNA sequences have the propensity to adopt four-stranded tetrahelical G-
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …

Heat shock proteins are essential molecular chaperones that play crucial roles in stabilizing
protein structures, facilitating the repair or degradation of damaged proteins, and …

The folding of the single-stranded 3′ end of the human telomere into G-quadruplex
arrangements inhibits the overhang from hybridizing with the RNA template of telomerase …

Human pancreatic ductal adenocarcinoma (PDAC) involves the dysregulation of multiple
signaling pathways. A novel approach to the treatment of PDAC is described, involving the …

G-quadruplex (G4) sequences, which can fold into higher-order G4 structures, are abundant
in the human genome and are over-represented in the promoter regions of many genes …

The tetrasubstituted naphthalene diimide compound QN-302 binds to G-quadruplex (G4)
DNA structures. It shows high potency in pancreatic ductal adenocarcinoma (PDAC) cells …

Abstract G-Quadruplex (G4) is one of the higher-order structures occurring in guanine-rich
sequences of nucleic acids, and plays critical roles in biological processes. The G4-forming …

Tetra-substituted naphthalene diimide (ND) derivatives with positively charged termini are
potent stabilizers of human telomeric and gene promoter DNA quadruplexes and inhibit the …