Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …

Thiazole, a five-membered heteroaromatic ring, is an important scaffold of a large number of
synthetic compounds. Its diverse pharmacological activity is reflected in many clinically …

A novel type of coumarin thiazoles as unique multi-targeting antimicrobial agents were
developed through four steps including cyclization, nucleophilic substitution and …

The struggle between humans and pathogens has taken and is continuing to take countless
lives every year. As the misusage of conventional antibiotics increases, the complexity …

Microtubules are cylindrical protein polymers formed from α β-tubulin heterodimers in the
cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the …

Abstract A new coumarin derivative, 7-((8-(4-benzylpiperidin-1-yl) octyl) oxy)-4-methyl-2H-
chromen-2-one (C3), was synthesized by two-step alkylation reaction of 7-hydroxy-4-methyl …

The emergence of drug-resistant microbes is responsible for high morbidity and mortality
worldwide. In our endeavors to cultivate novel and effectual antimicrobial agents, we present …

Considering the tremendous application of benzothiazole and its analogs in medicinal
chemistry, 2-amino-6-ethoxybenzothiazole (AEB) was selected to extensively investigate its …

Over the world and especially the developing countries, one of the major threats to human
health is antibiotic resistance due to antibiotics abuse. This challenge can be solved by …

In the present investigation, a series of 3-(1-(2-(thiazol-2-yl) hydrazineylidene) ethyl)-2H-
chromen-2-one derivatives are synthesized in good to excellent yield using PEG-400 as a …