One of the most significant challenges of inflammatory bowel disease (IBD) research is to
understand how alterations in the symbiotic relationship between the genetic composition of …

The human microbiota comprises trillions of symbiotic microorganisms and is involved in
regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis …

The gastrointestinal microbiome plays a pivotal role in physiological homeostasis of the
intestine as well as in the pathophysiology of diseases including inflammatory bowel …

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by progressive
polyarthritis that leads to cartilage and bone damage. Pre-clinical RA is a prolonged state …

Background The intestine of children with severe malnutrition (SM) shows structural and
functional changes that are linked to increased infection and mortality. SM dysregulates the …

Macroautophagy/autophagy is a highly conserved process in eukaryotic cells. It plays a
critical role in cellular homeostasis by delivering cytoplasmic cargos to lysosomes for …

Background Intestinal barrier dysfunction plays a central role in the pathological onset of
Crohn's disease. We identify the cadherin superfamily member protocadherin 20 (PCDH20) …

Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease, including
ulcerative colitis (UC) and Crohn's disease (CD). The abnormality of inflammatory and …

Ulcerative colitis (UC) is a chronic nonspecific inflammation that mainly affects the mucosa
and submucosa of the rectum and colon. Numerous studies have shown that endoplasmic …

Nucleic acid autoantibodies, increase type I interferon (IFN-α) levels, and immune cell
hyperactivation are hallmarks of systemic lupus erythematosus (SLE). Notably, immune cell …