The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …

The brain is vulnerable to excessive oxidative insults because of its abundant lipid content,
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …

Background: Cancer is considered a major cause of death worldwide. The etiology of cancer
is linked to environmental and genetic inheritance causes. Approximately 90 percent of all …

Hexavalent chromium is a highly soluble environmental contaminant. It is a widespread
anthropogenic chromium species that is 100 times more toxic than trivalent chromium …

Aerobic organisms possess numerous antioxidant enzymatic families, including catalases,
superoxide dismutases (SODs), peroxiredoxins (PRDXs), and glutathione peroxidases …

Photodynamic therapy (PDT) can be developed into an important arsenal against cancer; it
is a minimally invasive therapy, which is used in the treatment or/and palliation of a variety of …

Carcinogenesis is a multistep process involving mutation and the subsequent selective
clonal expansion of the mutated cell. Chemical and physical agents including those that …

Reactive Oxygen Species (ROS) are produced during normal cellular function. ROS include
hydroxyl radicals, superoxide anion, hydrogen peroxide and nitric oxide. They are very …

Significance: The mitochondrial antioxidant manganese superoxide dismutase (MnSOD) is
encoded by genomic DNA and its dismutase function is fully activated in the mitochondria to …

Catalase is an important antioxidant enzyme that dismutates hydrogen peroxide into water
and molecular oxygen. The catalase gene has all the characteristics of a housekeeping …