Highlights•Electrospun scaffolds physically mimic the native extracellular matrix.•Techniques
for physicochemical and biological characterization of scaffolds are discussed.•MSCs have …

Recent times have witnessed an upsurge in the incidence of neurodegenerative disorders
such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Prion disease, and …

Neurological function recovery after peripheral nerve injury (PNI) is exceptionally
challenging, chiefly because neurons cannot efficiently proliferate, differentiate, and form …

After many decades of biomaterials research for peripheral nerve regeneration, a clinical
product (the nerve guide), is emerging as a proven alternative for relatively short injury gaps …

Electrospun fibrous substrates mimicking extracellular matrices can be prepared by
electrospinning, yielding aligned fibrous matrices as internal fillers to manufacture artificial …

The use of bioengineered nerve guides as alternatives for autologous nerve transplantation
(ANT) is a promising strategy for the repair of peripheral nerve defects. In the present …

The structure and function of peripheral nerves can be affected by a range of conditions with
severe consequences in these patients. Currently, there are several surgical techniques …

Nanotechnology has considerably accelerated the growth of regenerative medicine in
recent years. Application of nanotechnology in regenerative medicine has revolutionized the …

Highlights•Coaxial electrospinning generates fibers with core–shell structure mimicking the
extracellular matrix.•Core–shell fibers are controlled delivery platforms of biocompounds for …

Highlights•Modern neurotrophin delivery systems should be able to cure neuronal
loss.•Gene carriers deliver stable neurotrophic proteins to specific brain regions.•Delivery …