To fully understand biological processes from the metabolism of a bacterium to the operation
of a human brain, it is necessary to know the three-dimensional (3D) spatial arrangement …

X-windows based microscopy image processing package (Xmipp) is a specialized suit of
image processing programs, primarily aimed at obtaining the 3D reconstruction of biological …

The recent mathematical concept of compressed sensing (CS) asserts that a small number
of well-chosen measurements can suffice to reconstruct signals that are amenable to sparse …

We describe a collection of standardized image processing protocols for electron
microscopy single-particle analysis using the XMIPP software package. These protocols …

A maximum-likelihood approach to multi-reference image refinement is presented. In
contrast to conventional cross-correlation refinement, the new approach includes a formal …

Two-dimensional analysis of projections of single-particles acquired by an electron
microscope is a useful tool to help identifying the different kinds of projections present in a …

This article presents a method to study large-scale conformational changes by combining
electron microscopy (EM) single-particle image analysis and normal mode analysis (NMA). It …

Three‐dimensional structure of a wide range of biological specimens can be computed from
images collected by transmission electron microscopy. This information integrated with …

Abstract Hybrid Electron Microscopy Normal Mode Analysis (HEMNMA) method was
introduced in 2014. HEMNMA computes normal modes of a reference model (an atomic …

The coexistence of multiple distinct structural states often obstructs the application of three-
dimensional cryo-electron microscopy to large macromolecular complexes. Maximum …