Hemostasis encompasses the tightly regulated processes of blood clotting, platelet
activation, and vascular repair. After wounding, the hemostatic system engages a plethora of …

Neutrophils play a critical role in the host defense against bacterial and fungal infections, but
their inappropriate activation also contributes to tissue damage during autoimmune and …

Neutrophil recruitment, lymphocyte recirculation and monocyte trafficking all require
adhesion and transmigration through blood-vessel walls. The traditional three steps of …

Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell
adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby …

When platelet numbers are low or when their function is disabled, the risk of bleeding is
high, which on the one hand indicates that in normal life vascular damage is a rather …

Inflammatory cell recruitment after myocardial infarction needs to be tightly controlled to
permit infarct healing while avoiding fatal complications such as cardiac rupture. Growth …

The majority of peripheral serotonin is stored in platelets, which secrete it on activation.
Serotonin releases Weibel-Palade bodies (WPBs) and we asked whether absence of …

The activation of leukocyte integrins through diverse receptors results in transformation of
the integrin from a bent, resting form to an extended conformation, which has at least two …

Tumor inflammation promotes angiogenesis, immunosuppression, and tumor growth, but the
mechanisms controlling inflammatory cell recruitment to tumors are not well understood. We …

Integrins are the principal cell adhesion receptors that mediate leukocyte migration and
activation in the immune system. These receptors signal bidirectionally through the plasma …