The majority of energy consumed by contracting muscle can be accounted for by two ATP-
dependent processes, cross-bridge cycling and Ca 2+ cycling. The energy for Ca 2+ cycling …

Skeletal muscle excitation–contraction (E–C) 1 coupling is a process composed of multiple
sequential stages, by which an action potential triggers sarcoplasmic reticulum (SR) 2 Ca2+ …

Reduced homeostatic capacity for intracellular Ca2+ ([Ca2+] i) movement may underlie the
progression of sarcopenia and contractile dysfunction during muscle aging. We report two …

Abstract Calpain-3 (CAPN3) is a non-lysosomal cysteine protease that is necessary for
normal muscle function, as mutations in CAPN3 result in an autosomal recessive form of …

Skeletal muscle protein synthesis rate decreases during contractions but the underlying
regulatory mechanisms are poorly understood. It was hypothesized that there would be a …

Lengthening of active muscle is an essential feature of animal locomotion, but the molecular
processes occurring are incompletely understood. We therefore examined and modelled …

The sliding filament–swinging cross bridge theory of skeletal muscle contraction provides a
reasonable description of muscle properties during isometric contractions at or near …

We examined the tension responses to ramp shortening and lengthening over a range of
velocities (0.1–5 L 0/s) and at 20° C and 30° C in tetanized intact fibre bundles from a rat fast …

Stretching of activated skeletal muscles induces a force increase above the isometric level
persisting after stretch, known as residual force enhancement (RFE). RFE has been …

Calpains are Ca2+‐activated proteases that are thought to be involved in muscle
degenerative diseases such as Duchenne muscular dystrophy. Status and activity of …