Currently, about 40% of approved drugs and nearly 90% of drug candidates are poorly
water-soluble drugs. Low solubility reduces the likelihood that these drugs can be effectively …

Introduction The nose-to-brain route has been widely investigated to improve drug targeting
to the central nervous system (CNS), where lipid nanoparticles (solid lipid nanoparticles …

Stroke is a devastating neurological disorder that is characterized by the sudden disruption
of blood flow to the brain. Lipids are essential components of brain structure and function …

The unique anatomical and physiological connections between the nasal cavity and brain
provide a pathway for bypassing the blood–brain barrier to allow for direct brain-targeted …

Epilepsy is a highly prevalent neurological disease and valproic acid (VPA) is used as a first-
line chronic treatment. However, this drug has poor oral bioavailability, which requires the …

In an effort to tackle the skin reactions frequently observed with topical application of
ivermectin (IVM), a study was conducted to develop and optimize transethosomes (TESMs) …

Traditional energy from fossil fuels like petroleum and coal is limited and contributes to
global environmental pollution and climate change. Developing sustainable and eco …

Brain cancer pose significant life-threats by destructively invading normal brain tissues,
causing dysneuria, disability and death, and its therapeutics is limited by underdosage and …

Every year> 15 million individuals globally affect with a stroke and is considered the second
leading cause of mortality among all neurological disorders. Though numerous …

Candesartan (CDN) is a useful anti-stroke medication because it lowers blood pressure,
inflammation, oxidative stress, angiogenesis and apoptosis. However, CDN has limited …