Advanced model systems and tools for basic and translational human immunology
There are fundamental differences between humans and the animals we typically use to
study the immune system. We have learned much from genetically manipulated and inbred …
study the immune system. We have learned much from genetically manipulated and inbred …
Towards systems immunology of critical illness at scale: from single cell 'omics to digital twins
Y Vodovotz - Trends in immunology, 2023 - cell.com
Single-cell 'omics methodology has yielded unprecedented insights based largely on data-
centric informatics for reducing, and thus interpreting, massive datasets. In parallel …
centric informatics for reducing, and thus interpreting, massive datasets. In parallel …
Mechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2
SARS-CoV-2 vaccines are effective at limiting disease severity, but effectiveness is lower
among patients with cancer or immunosuppression. Effectiveness wanes with time and …
among patients with cancer or immunosuppression. Effectiveness wanes with time and …
Integrating single-cell multi-omics and prior biological knowledge for a functional characterization of the immune system
The immune system comprises diverse specialized cell types that cooperate to defend the
host against a wide range of pathogenic threats. Recent advancements in single-cell and …
host against a wide range of pathogenic threats. Recent advancements in single-cell and …
Challenges in personalized nutrition and health
Personalized nutrition refers to tailored nutritional recommendations aimed at the promotion,
maintenance of health and prevention against diseases (1). These recommendations take …
maintenance of health and prevention against diseases (1). These recommendations take …
Systems biology of malaria explored with nonhuman primates
MR Galinski - Malaria journal, 2022 - Springer
Abstract “The Primate Malarias” book has been a uniquely important resource for multiple
generations of scientists, since its debut in 1971, and remains pertinent to the present day …
generations of scientists, since its debut in 1971, and remains pertinent to the present day …
Approaches and advances in the genetic causes of autoimmune disease and their implications
JRJ Inshaw, AJ Cutler, OS Burren, MI Stefana… - Nature …, 2018 - nature.com
Genome-wide association studies are transformative in revealing the polygenetic basis of
common diseases, with autoimmune diseases leading the charge. Although the field is just …
common diseases, with autoimmune diseases leading the charge. Although the field is just …
Sex and gender in infection and immunity: addressing the bottlenecks from basic science to public health and clinical applications
C Pasin, CR Consiglio, JS Huisman… - Royal Society …, 2023 - royalsocietypublishing.org
Although sex and gender are recognized as major determinants of health and immunity,
their role is rarely considered in clinical practice and public health. We identified six …
their role is rarely considered in clinical practice and public health. We identified six …
Mapping CAR T-cell design space using agent-based models
Chimeric antigen receptor (CAR) T-cell therapy shows promise for treating liquid cancers
and increasingly for solid tumors as well. While potential design strategies exist to address …
and increasingly for solid tumors as well. While potential design strategies exist to address …
Toward a model-free feedback control synthesis for treating acute inflammation
An effective and patient-specific feedback control synthesis for inflammation resolution is still
an ongoing research area. A strategy consisting of manipulating a pro and anti-inflammatory …
an ongoing research area. A strategy consisting of manipulating a pro and anti-inflammatory …