After a quarter century of rapid advances, cancer research has generated a rich and
complex body of knowledge, revealing cancer to be a disease involving dynamic changes in …

In addition to their adhesive functions, cell-adhesion molecules modulate signal-
transduction pathways by interacting with molecules such as receptor tyrosine kinases …

Approximately 90% of all cancer deaths arise from the metastatic spread of primary tumours.
Of all the processes involved in carcinogenesis, local invasion and the formation of …

Metastasis, the spread of malignant cells from a primary tumor to distant sites, poses the
biggest problem to cancer treatment and is the main cause of death of cancer patients. It …

Metastasis is a frequent and lethal complication of cancer. Vascular endothelial growth
factor‐C (VEGF‐C) is a recently described lymphangiogenic factor. Increased expression of …

Multistep carcinogenesis involves more than six discrete events also important in normal
development and cell behavior. Of these, local invasion and metastasis cause most cancer …

Fibroblast growth factor (FGF) signaling regulates cell proliferation, differentiation, survival,
angiogenesis, and wound healing. Compelling evidence for deregulated FGF signaling in …

Metastasis is the result of cancer cell adaptation to a tissue microenvironment at a distance
from the primary tumor. Metastatic cancer cells require properties that allow them not only to …

Sialic acids are widely expressed as terminal carbohydrates on glycoconjugates of
eukaryotic cells. Sialylation is crucial for a variety of cellular functions, such as cell adhesion …

Previously we observed that neural cell adhesion molecule (NCAM) deficiency in β tumor
cells facilitates metastasis into distant organs and local lymph nodes. Here, we show that …