Cascade synthetic strategies opening access to medicinal-relevant aliphatic 3-and 4-membered N-heterocyclic scaffolds

D Łowicki, P Przybylski - European Journal of Medicinal Chemistry, 2022 - Elsevier
Cascade reactions are often 'employed'by nature to construct structurally diverse nitrogen-
containing heterocycles in a highly stereoselective fashion, ie, secondary metabolites …

Tunable Aziridinium Ylide Reactivity: Noncovalent Interactions Enable Divergent Product Outcomes

KA Nicastri, SA Zappia, JC Pratt, JM Duncan… - ACS …, 2022 - ACS Publications
Methods for rapid preparation of densely functionalized and stereochemically complex N-
heterocyclic scaffolds are in demand for exploring the potential bioactive chemical space …

Solvent-Controlled Regioselective Reaction of 2-Methyleneaziridines with Acrylic/Propargylic Acids: Synthesis of Carboxylate Aziridine/Acetone Esters

B Pan, HT Sun, SS Zhang, S Wang, YQ Yang… - Organic …, 2022 - ACS Publications
Herein, we report a convenient solvent-controlled regioselective esterification to access two
types of carboxylate esters without any additive or non-green activation strategy. In this …

Structural and chiroptical analysis of naturally occurring (–)-strychnine

F Reinscheid, M Schmidt, H Abromeit, S Liening… - Journal of Molecular …, 2016 - Elsevier
Structural aspects such as chemical exchange, dimerization, solvent association, nitrogen
inversion and protonation status of strychnine were investigated using experimental and …

Design of a new rotary molecular machine based on nitrogen inversion: a DFT investigation

SS Gorgani, M Samadizadeh - Journal of Structural Chemistry, 2016 - Springer
Ab initio calculations are employed to investigate nitrogen inversion as a configuration
change that can supply an extremely useful switchable control mechanism for some …

[PDF][PDF] Aziridines and their asymmetric conversion to bioactive compounds

SAGS Silva - core.ac.uk
A method for the preparation of optically active cyclic 4-hydroxyacylazyridines ((x+ 1)-
hydroxyazabicyclo [x. 1.0] alkane-2-ones) is described. It is based on the stereoselective …

Synthesis of FtsZ inhibitors: potential antibiotic agents

M Payne - 2019 - opus.lib.uts.edu.au
In April 2014, the World Health Organisation (WHO) acknowledged the immediate threat of
antibacterial resistance and the impact it will have on modern medicine. The greatest …

Mechanically Coupled Molecular Rotors Built with Bis (triazolo) benzene Scaffolds

김도담 - 2018 - s-space.snu.ac.kr
In this Thesis are described conformationally well-defined synthetic systems named as triple-
deckers, which are designed to mimic and better understand the compact three-dimensional …