Biofilm regulation in Clostridioides difficile: Novel systems linked to hypervirulence
MG Taggart, WJ Snelling, PJ Naughton… - PLoS …, 2021 - journals.plos.org
Clostridiodes difficile (C. difficile) was ranked an “urgent threat” by the Centers for Disease
Control and Prevention (CDC) in 2019. C. difficile infection (CDI) is the most common …
Control and Prevention (CDC) in 2019. C. difficile infection (CDI) is the most common …
Intestinal biofilms: pathophysiological relevance, host defense, and therapeutic opportunities
The human intestinal tract harbors a profound variety of microorganisms that live in
symbiosis with the host and each other. It is a complex and highly dynamic environment …
symbiosis with the host and each other. It is a complex and highly dynamic environment …
Diversity, Dynamics and Therapeutic Application of Clostridioides difficile Bacteriophages
Clostridioides difficile causes antibiotic-induced diarrhoea and pseudomembranous colitis
in humans and animals. Current conventional treatment relies solely on antibiotics, but C …
in humans and animals. Current conventional treatment relies solely on antibiotics, but C …
Transcriptomic analysis of biofilm formation in strains of Clostridioides difficile associated with recurrent and non-recurrent infection reveals potential candidate …
D Rubio-Mendoza, C Córdova-Fletes… - Plos one, 2023 - journals.plos.org
The transcriptomic profile in a biofilm model of ribotypes (RT) 001 and 027 associated with
recurrent Clostridioides difficile infection (R-CDI) and not associated with recurrent (NR)-CDI …
recurrent Clostridioides difficile infection (R-CDI) and not associated with recurrent (NR)-CDI …
Clostridioides difficile recurrence in individuals with and without cancer: a Swedish population-based cohort study
Purpose Patients with cancer are vulnerable to Clostridioides difficile infection (CDI) due to
their disease, treatment and regular hospital contact, yet if CDI-recurrence is more common …
their disease, treatment and regular hospital contact, yet if CDI-recurrence is more common …
Therapeutic effects of Bifidobacterium breve YH68 in combination with Vancomycin and metronidazole in a primary clostridioides difficile-infected mouse model
Probiotics have been widely used to prevent primary Clostridioides difficile infection (pCDI);
however, there are fewer studies on their therapeutic aspects for pCDI. In this study, high …
however, there are fewer studies on their therapeutic aspects for pCDI. In this study, high …
An osmotic laxative renders mice susceptible to prolonged Clostridioides difficile colonization and hinders clearance
Antibiotics are a major risk factor for Clostridioides difficile infections (CDIs) because of their
impact on the microbiota. However, nonantibiotic medications such as the ubiquitous …
impact on the microbiota. However, nonantibiotic medications such as the ubiquitous …
Clostridioides difficile infection study models and prospectives for probing the microbe-host interface
T Zvonareva, DS Courson, EB Purcell - Journal of Bacteriology, 2025 - journals.asm.org
Clostridioides difficile infection (CDI) is an urgent public health threat with a high rate of
recurrence and limited treatment options. In vivo models have been indispensable in …
recurrence and limited treatment options. In vivo models have been indispensable in …
Host-defense piscidin peptides as antibiotic adjuvants against Clostridioides difficile
The spore-forming intestinal pathogen Clostridioides difficile causes multidrug resistant
infection with a high rate of recurrence after treatment. Piscidins 1 (p1) and 3 (p3), cationic …
infection with a high rate of recurrence after treatment. Piscidins 1 (p1) and 3 (p3), cationic …
Pre-colonization with the fungus Candida glabrata exacerbates infection by the bacterial pathogen Clostridioides difficile in a murine model
JA Romo, M Tomihiro, CA Kumamoto - Msphere, 2023 - Am Soc Microbiol
The contributions of commensal fungi to human health and disease are not well understood.
Candida species such as C. albicans and C. glabrata are opportunistic pathogenic fungi and …
Candida species such as C. albicans and C. glabrata are opportunistic pathogenic fungi and …