Harnessing the power of artificial intelligence to advance cell therapy

S Capponi, KG Daniels - Immunological Reviews, 2023 - Wiley Online Library
Cell therapies are powerful technologies in which human cells are reprogrammed for
therapeutic applications such as killing cancer cells or replacing defective cells. The …

Cancer therapy with antibodies

S Paul, MF Konig, DM Pardoll, C Bettegowda… - Nature Reviews …, 2024 - nature.com
The greatest challenge in cancer therapy is to eradicate cancer cells with minimal damage
to normal cells. Targeted therapy has been developed to meet that challenge, showing a …

Identifying Umami Peptides Specific to the T1R1/T1R3 Receptor via Phage Display

M Li, X Zhang, Y Zhu, X Zhang, Z Cui… - Journal of Agricultural …, 2023 - ACS Publications
Umami peptides are small molecular weight oligopeptides that play a role in umami taste
attributes. However, the identification of umami peptides is easily limited by environmental …

[HTML][HTML] A dendritic/tumor fusion cell vaccine enhances efficacy of nanobody-based CAR-T cells against solid tumor

S Sun, Z Ding, L Gao, BD Hammock, X Huang… - Theranostics, 2023 - ncbi.nlm.nih.gov
Background: Chimeric antigen receptor (CAR) T-cell therapy is practical in treating cancers
of hematopoietic origin, but of that in solid tumors compromises efficacy for the loss of the …

[HTML][HTML] Alternative target recognition elements for chimeric antigen receptor (CAR) T cells: beyond standard antibody fragments

MA Nix, AP Wiita - Cytotherapy, 2024 - Elsevier
Background aims Chimeric antigen receptor T (CAR-T) cells are a remarkably efficacious,
highly promising and rapidly evolving strategy in the field of immuno-oncology. The …

Strategies for enhancing CAR T cell expansion and persistence in HIV infection

FH Rothemejer, NP Lauritsen, OS Søgaard… - Frontiers in …, 2023 - frontiersin.org
Chimeric Antigen Receptor (CAR) T cell therapies are tremendously successful in
hematological malignancies and show great promise as treatment and curative strategy for …

The prospect of harnessing the microbiome to improve immunotherapeutic response in pancreatic cancer

S Rogers, A Charles, RM Thomas - Cancers, 2023 - mdpi.com
Simple Summary Pancreatic cancer is an insidious disease, often diagnosed late in its
course when curative treatments are moot, with a 5-year median overall survival of~ 12 …

[HTML][HTML] Expand available targets for CAR-T therapy to overcome tumor drug resistance based on the" Evolutionary Traps"

X Wang, P Wang, Y Liao, X Zhao, R Hou, S Li… - Pharmacological …, 2024 - Elsevier
Based on the concept of" Evolutionary Traps", targeting survival essential genes obtained
during tumor drug resistance can effectively eliminate resistant cells. While, it still faces …

[HTML][HTML] Synthetic Cells and Molecules in Cellular Immunotherapy

H Lin, C Li, W Zhang, B Wu, Y Wang… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Cellular immunotherapy has emerged as an exciting strategy for cancer treatment, as it aims
to enhance the body's immune response to tumor cells by engineering immune cells and …

Research advances of nanoparticles for CAR-T therapy in solid tumors

B Chen, L Gong, J Feng, M Jin, L Chen, Z Gao… - Chinese Chemical …, 2023 - Elsevier
As one of the most promising adoptive T-cell therapies, chimeric antigen receptor T-cell
(CAR-T) therapy has acquired Food and Drug Administration (FDA) approval for a variety of …